Interleukin-5 enhances the migration and invasion of bladder cancer cells via ERK1/2-mediated MMP-9/NF-κB/AP-1 pathway: involvement of the p21WAF1 expression

EJ Lee, SJ Lee, S Kim, SC Cho, YH Choi, WJ Kim… - Cellular signalling, 2013 - Elsevier
Inflammatory cytokines may be a critical component of epithelial cancer progression. We
examined the role of interleukin (IL)-5 in the migration of bladder cancer cells. The …

Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (ERK)-mediated MMP-9 protein expression leading to nuclear …

SJ Lee, SC Cho, EJ Lee, S Kim, SB Lee, JH Lim… - Journal of Biological …, 2013 - ASBMB
The role of inflammatory cytokine interleukin-20 (IL-20) has not yet been studied in cancer
biology. Here, we demonstrated up-regulation of both IL-20 and IL-20R1 in muscle-invasive …

Identification of pro-inflammatory cytokines associated with muscle invasive bladder cancer; the roles of IL-5, IL-20, and IL-28A

SJ Lee, EJ Lee, SK Kim, P Jeong, YH Cho, SJ Yun… - PloS one, 2012 - journals.plos.org
We used gene expression profiling to identify inflammatory cytokines that correlate with
bladder cancer development. Gene expression profiles of the tissue samples were …

Interleukin-28A triggers wound healing migration of bladder cancer cells via NF-κB-mediated MMP-9 expression inducing the MAPK pathway

SJ Lee, JH Lim, YH Choi, WJ Kim, SK Moon - Cellular Signalling, 2012 - Elsevier
Interleukin (IL)-28A, also called IFN-λ2, is a member of the classIIcytokine family and has
demonstrated anti-proliferative and anti-viral signals. The present study demonstrated …

p27KIP1 is involved in ERK1/2-mediated MMP-9 expression via the activation of NF-κB binding in the IL-7-induced migration and invasion of 5637 cells

SL Park, EJ Lee, WJ Kim… - … Journal of Oncology, 2014 - spandidos-publications.com
Abstract Interleukin-7 (IL-7) plays a pivotal role in the development and survival of
lymphocytes, but its role in cancer cell responses remains unexplained. In this study, IL-7 …

IL‐6 promotes the proliferation and immunosuppressive function of myeloid‐derived suppressor cells via the MAPK signaling pathway in bladder cancer

Z Zheng, X Zheng, Y Zhu, Z Yao, W Zhao… - BioMed Research …, 2021 - Wiley Online Library
Muscle‐invasive bladder cancer (MIBC) is characterized by a highly complex immune
environment, which is not well understood. Interleukin‐6 (IL‐6) is generated and secreted by …

Regulation of TLR4-induced IL-6 response in bladder cancer cells by opposing actions of MAPK and PI3K signaling

Y Qian, J Deng, H Xie, L Geng, L Zhou, Y Wang… - Journal of cancer …, 2009 - Springer
Purpose Toll-like receptor 4 (TLR4) was found to be aberrantly expressed in bladder cancer,
inducing some genes expression and facilitating tumor progression. Recent data suggest …

Nuclear factor-κB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8

T Karashima, P Sweeney, A Kamat, S Huang… - Clinical Cancer …, 2003 - AACR
Abstract Purpose: Interleukin (IL)-8 is an important mediator of angiogenesis, tumorigenicity,
and metastasis in transitional cell carcinoma (TCC) of the bladder. Nuclear factor κB (NF …

Mechanisms by which interleukin‐6 attenuates cell invasion and tumorigenesis in human bladder carcinoma cells

KH Tsui, SW Wang, LC Chung, TH Feng… - BioMed Research …, 2013 - Wiley Online Library
Interleukin‐6, a multifunctional cytokine, contributes to tumor cell proliferation and
differentiation. However, the biological mechanisms that are affected by the expression of …

Interleukin 8 expression regulates tumorigenicity and metastasis in human bladder cancer

K Inoue, JW Slaton, SJ Kim, P Perrotte, BY Eve… - Cancer research, 2000 - AACR
Abstract Interleukin 8 (IL-8) is mitogenic and chemotactic for endothelial cells. Within a
neoplasm, IL-8 is secreted by inflammatory and neoplastic cells. The highly tumorigenic and …