Topography of extracellular matrix mediates vascular morphogenesis and migration speeds in angiogenesis
The extracellular matrix plays a critical role in orchestrating the events necessary for wound
healing, muscle repair, morphogenesis, new blood vessel growth, and cancer invasion. In …
healing, muscle repair, morphogenesis, new blood vessel growth, and cancer invasion. In …
Extracellular matrix density regulates the rate of neovessel growth and branching in sprouting angiogenesis
Angiogenesis is regulated by the local microenvironment, including the mechanical
interactions between neovessel sprouts and the extracellular matrix (ECM). However, the …
interactions between neovessel sprouts and the extracellular matrix (ECM). However, the …
Direct comparison of angiogenesis in natural and synthetic biomaterials reveals that matrix porosity regulates endothelial cell invasion speed and sprout diameter
Vascularization of large, diffusion-hindered biomaterial implants requires an understanding
of how extracellular matrix (ECM) properties regulate angiogenesis. Sundry biomaterials …
of how extracellular matrix (ECM) properties regulate angiogenesis. Sundry biomaterials …
Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation
Angiogenesis is a complex morphogenetic process that involves intimate interactions
between multicellular endothelial structures and their extracellular milieu. In vitro models of …
between multicellular endothelial structures and their extracellular milieu. In vitro models of …
A cell-based model of extracellular-matrix-guided endothelial cell migration during angiogenesis
Angiogenesis, the formation of new blood vessels sprouting from existing ones, occurs in
several situations like wound healing, tissue remodeling, and near growing tumors. Under …
several situations like wound healing, tissue remodeling, and near growing tumors. Under …
Mechanisms of vascular endothelial growth factor-induced pathfinding by endothelial sprouts in biomaterials
A Shamloo, H Xu, S Heilshorn - Tissue Engineering Part A, 2012 - liebertpub.com
A critical property of biomaterials for use in regenerative medicine applications is the ability
to promote angiogenesis, the formation of new vascular networks, to support regenerating …
to promote angiogenesis, the formation of new vascular networks, to support regenerating …
Angiogenesis
DR Senger, GE Davis - Cold Spring Harbor perspectives …, 2011 - cshperspectives.cshlp.org
Extracellular matrix (ECM) is essential for all stages of angiogenesis. In the adult,
angiogenesis begins with endothelial cell (EC) activation, degradation of vascular basement …
angiogenesis begins with endothelial cell (EC) activation, degradation of vascular basement …
Matrix density mediates polarization and lumen formation of endothelial sprouts in VEGF gradients
A Shamloo, SC Heilshorn - Lab on a Chip, 2010 - pubs.rsc.org
Endothelial cell (EC) sprouting morphogenesis is a critical step during angiogenesis, the
formation of new blood vessels from existing conduits. Here, three-dimensional sprouting …
formation of new blood vessels from existing conduits. Here, three-dimensional sprouting …
Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms
CM Ghajar, S Kachgal, E Kniazeva, H Mori… - Experimental cell …, 2010 - Elsevier
During angiogenesis, endothelial cells (ECs) degrade their surrounding extracellular matrix
(ECM) to facilitate invasion. How interactions between ECs and other cells within their …
(ECM) to facilitate invasion. How interactions between ECs and other cells within their …
A novel, quantitative model for study of endothelial cell migration and sprout formation within three-dimensional collagen matrices
RB Vernon, EH Sage - Microvascular research, 1999 - Elsevier
Interactions between migratory endothelial cells (ECs) and surrounding extracellular matrix
(ECM) are of central importance to vascular growth. Here, we present a new model of EC …
(ECM) are of central importance to vascular growth. Here, we present a new model of EC …