The extracellular matrix plays a critical role in orchestrating the events necessary for wound
healing, muscle repair, morphogenesis, new blood vessel growth, and cancer invasion. In …

Angiogenesis is regulated by the local microenvironment, including the mechanical
interactions between neovessel sprouts and the extracellular matrix (ECM). However, the …

Vascularization of large, diffusion-hindered biomaterial implants requires an understanding
of how extracellular matrix (ECM) properties regulate angiogenesis. Sundry biomaterials …

Angiogenesis is a complex morphogenetic process that involves intimate interactions
between multicellular endothelial structures and their extracellular milieu. In vitro models of …

Angiogenesis, the formation of new blood vessels sprouting from existing ones, occurs in
several situations like wound healing, tissue remodeling, and near growing tumors. Under …

A critical property of biomaterials for use in regenerative medicine applications is the ability
to promote angiogenesis, the formation of new vascular networks, to support regenerating …

Extracellular matrix (ECM) is essential for all stages of angiogenesis. In the adult,
angiogenesis begins with endothelial cell (EC) activation, degradation of vascular basement …

Endothelial cell (EC) sprouting morphogenesis is a critical step during angiogenesis, the
formation of new blood vessels from existing conduits. Here, three-dimensional sprouting …

During angiogenesis, endothelial cells (ECs) degrade their surrounding extracellular matrix
(ECM) to facilitate invasion. How interactions between ECs and other cells within their …

Interactions between migratory endothelial cells (ECs) and surrounding extracellular matrix
(ECM) are of central importance to vascular growth. Here, we present a new model of EC …