Endoplasmic reticulum (ER) stress and mitochondrial dysfunction, which are key events in
the initiation and/or progression of several diseases, are correlated with alterations at ER …

Endoplasmic reticulum (ER) stress is observed in many human diseases, often associated
with inflammation. ER stress can trigger inflammation through nucleotide-binding domain …

Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) is a crucial component of the cellular
machinery responsible for Ca2+ homeostasis. The selective inhibition of SERCA by …

Mitochondria and the endoplasmic reticulum (ER) are fundamental organelles that
coordinate high-order cell functions. Mitochondria are centers of energy production …

NLRP3 inflammasome‐dependent inflammatory responses are triggered by a variety of
signals of host danger, including infection, tissue damage and metabolic dysregulation. How …

Despite the fact that deregulated NLRP3 inflammasome activation contributes to the
pathogenesis of chronic inflammatory or metabolic disorders, the underlying mechanism by …

Mitochondria, the dynamic organelles and power house of eukaryotic cells function as
metabolic hubs of cells undergoing continuous cycles of fusion and fission. Recent findings …

The NLRP3 inflammasome, as an important component of the innate immune system, plays
vital roles in various metabolic disorders. It has been reported that the NLRP3 …

The nod‐like receptor protein 3 (NLRP3) inflammasome drives inflammation in response to
mitochondrial dysfunction. As metabolic powerhouses with prokaryotic ancestry …

The NLRP3 inflammasome is a cytosolic complex that activates Caspase-1, leading to
maturation of interleukin-1β (IL-1β) and IL-18 and induction of proinflammatory cell death in …