[HTML][HTML] The importance of synovial inflammation in osteoarthritis: current evidence from imaging assessments and clinical trials

X Wang, DJ Hunter, X Jin, C Ding - Osteoarthritis and cartilage, 2018 - Elsevier
Synovial abnormalities have been observed at multiple stages of osteoarthritis (OA).
Increasing evidence suggests that it may play an important role in the OA pathological …

[HTML][HTML] Synovitis in osteoarthritis: current understanding with therapeutic implications

A Mathiessen, PG Conaghan - Arthritis research & therapy, 2017 - Springer
Modern concepts of osteoarthritis (OA) have been forever changed by modern imaging
phenotypes demonstrating complex and multi-tissue pathologies involving cartilage …

The role of synovitis in osteoarthritis pathogenesis

CR Scanzello, SR Goldring - Bone, 2012 - Elsevier
Research into the pathophysiology of osteoarthritis (OA) has focused on cartilage and peri-
articular bone, but there is increasing recognition that OA affects all of the joint tissues …

Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges

M Rahmati, A Mobasheri, M Mozafari - Bone, 2016 - Elsevier
Osteoarthritis (OA) has traditionally been defined as a prototypical non-inflammatory
arthropathy, but today there is compelling evidence to suggest that it has an inflammatory …

[HTML][HTML] Inflammatory biomarkers in osteoarthritis

HN Daghestani, VB Kraus - Osteoarthritis and cartilage, 2015 - Elsevier
Osteoarthritis (OA) is highly prevalent and a leading cause of disability worldwide. Despite
the global burden of OA, diagnostic tests and treatments for the molecular or early …

Imaging of synovitis in osteoarthritis: current status and outlook

D Hayashi, FW Roemer, A Katur, DT Felson… - Seminars in arthritis and …, 2011 - Elsevier
OBJECTIVES: This review article provides an overview of the current state of imaging of
synovitis in osteoarthritis (OA), looking at recent advances and controversies and focusing …

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

J Sellam, F Berenbaum - Nature Reviews Rheumatology, 2010 - nature.com
Osteoarthritis (OA), one of the most common rheumatic disorders, is characterized by
cartilage breakdown and by synovial inflammation that is directly linked to clinical symptoms …

The role of synovitis in osteoarthritis

CYJ Wenham, PG Conaghan - Therapeutic advances in …, 2010 - journals.sagepub.com
Osteoarthritis (OA) is the most common form of arthritis worldwide yet there is still a lack of
effective treatments for this condition. Increasingly, attention has turned to the role of the …

Imaging research results from the Osteoarthritis Initiative (OAI): a review and lessons learned 10 years after start of enrolment

F Eckstein, CK Kwoh, TM Link… - Annals of the rheumatic …, 2014 - ard.bmj.com
The Osteoarthritis Initiative (OAI) is a multicentre, prospective, observational, cohort study of
knee osteoarthritis (OA) that began recruitment in 2004. The OAI provides public access to …

Inflammation (or synovitis)-driven osteoarthritis: an opportunity for personalizing prognosis and treatment?

AS Siebuhr, AC Bay-Jensen, JM Jordan… - Scandinavian journal …, 2016 - Taylor & Francis
The disabling and painful disease osteoarthritis (OA) is the most common form of arthritis.
Strong evidence suggests that a subpopulation of OA patients has a form of OA driven by …