Most of the vaccines available today, albeit very effective, have been developed using
traditional “old-style” methodologies. Technologies developed in recent years have opened …

Reverse vaccinology defines the process of antigen discovery starting from genome
information. From its first application to Neisseria meningitidis group B, this approach has …

Whole genome sequence data are increasingly available for a wide range of human
pathogens. The use of bioinformatic tools allows the comprehensive in silico screening of …

During the last century, several approaches have been used for the development of
vaccines, going from the immunization with live-attenuated bacteria up to the formulation of …

During the last century several approaches have been followed for the development of
vaccines. These include live-attenuated viruses and bacteria, killed microorganisms and the …

Reverse vaccinology (RV) is a computational approach that aims to identify putative vaccine
candidates in the protein coding genome (proteome) of pathogens. RV has primarily been …

Reverse vaccinology (RV) was first introduced by Rappuoli for the development of an
effective vaccine against serogroup B Neisseria meningitidis (MenB). With the advances in …

The conventional approach to vaccine development is based on dissection of the pathogen
using biochemical, immunological and microbiological methods. Although successful in …

The discovery of vaccine antigens through whole genome sequencing (WGS) contrasts with
the classical hypothesis-driven laboratory-based analysis of microbes to identify …

Whole-genome sequencing of bacteria and advances in bioinformatics have revolutionized
the vaccinology field, leading to the identification of potential vaccine candidates without the …