Low hair copper concentration is related to a high risk of nonalcoholic fatty liver disease in adults

SH Lee, MJ Kim, YS Kim, H Chun, BY Won… - Journal of Trace …, 2018 - Elsevier
Copper, an essential micronutrient, is required for lipid metabolism, mitochondrial function,
iron metabolism, and antioxidant defense. Copper deficiency has been linked to alterations …

Copper Deficiency Reduces Insulin Receptor and AKT Activation in Mouse Hepatocytes

H Odom - 2024 - digitalcommons.unl.edu
The liver is an essential organ for nutrient metabolism, and metabolic diseases, such as non-
alcoholic fatty liver disease (NAFLD), affect its functions. NAFLD is characterized by …

Hepatic copper metabolism: insights from genetic disease

TY Tao, JD Gitlin - Hepatology, 2003 - journals.lww.com
Copper is an essential dietary nutrient. This metal facilitates electron transfer reactions when
incorporated into specific cuproproteins and is utilized for such diverse processes as …

High Iron Consumption Modifies the Hepatic Transcriptome Related to Cholesterol Metabolism

J Lee, H Jang, M Doo, BH Kim, JH Ha - Journal of Medicinal Food, 2024 - liebertpub.com
Iron supplementation is a common method for alleviating symptoms of iron deficiency, but
excessive iron intake may lead to systemic copper deficiencies and hypercholesterolemia. In …

Tissue-specific alterations in lipoprotein lipase activity in copper-deficient rats

REC Wildman, S Mao - Biological Trace Element Research, 2001 - Springer
Copper deficiency results in alterations in lipid metabolism that include elevations in serum
cholesterol and triglycerides and a decrease in whole-body respiratory quotient. Copper …

Association between blood copper and nonalcoholic fatty liver disease according to sex

Y Lan, S Wu, Y Wang, S Chen, W Liao, X Zhang, L Pan… - Clinical Nutrition, 2021 - Elsevier
Background & aims Nonalcoholic fatty liver disease (NAFLD) is a common disease with
potential sex-based difference in the prevalence and prognosis. Copper deficiency may …

Obesity is associated with copper elevation in serum and tissues

H Yang, CN Liu, RM Wolf, M Ralle, S Dev… - Metallomics, 2019 - academic.oup.com
Copper misbalance has been linked to fat accumulation in animals and experimental
systems; however, information about copper homeostasis in human obesity is limited. In this …

Copper and lipid metabolism: a reciprocal relationship

B Blades, S Ayton, YH Hung, AI Bush… - Biochimica et Biophysica …, 2021 - Elsevier
Background Copper and lipid metabolism are intimately linked, sharing a complex, inverse
relationship in the periphery (outside of the central nervous system), which remains to be …

Copper deficiency increases in vivo hepatic synthesis of fatty acids, triacylglycerols, and phospholipids in rats

AA Al-Othman, F Rosenstein… - Proceedings of the …, 1993 - journals.sagepub.com
This study examined the influence of dietary copper status on the in vivo hepatic fatty acid
synthesis and the incorporation of nascent fatty acids into various hepatic lipid classes. Fifty …

Modest fructose beverage intake causes liver injury and fat accumulation in marginal copper deficient rats

M Song, DA Schuschke, Z Zhou, T Chen, X Shi… - …, 2013 - Wiley Online Library
Objective Dietary fructose and copper interaction may play an important role in the
pathogenesis of nonalcoholic fatty liver disease. In this study, whether or not modest fructose …