Genomic DNA is under constant attack from both endogenous and exogenous sources of
DNA damaging agents. Without proper care, the ensuing DNA damages would lead to …

In response to genomic insults cells trigger a signal transduction pathway, known as DNA
damage checkpoint, whose role is to help the cell to cope with the damage by coordinating …

DNA damage response mechanisms encompass pathways of DNA repair, cell cycle
checkpoint arrest and apoptosis. Together, these mechanisms function to maintain genomic …

Cell cycle checkpoint activation and DNA repair pathways govern genomic stability after
genotoxic stress. Genotoxic insult results in activation of an interwoven network of DNA …

The genome integrity checkpoint is a conserved signaling pathway that is regulated in yeast
by the Mec1 (homologous to human ATR) and Rad53 (homologous to human Chk1) …

In response to even a single chromosomal double-strand DNA break, cells enact the DNA
damage checkpoint. This checkpoint triggers cell cycle arrest, providing time for the cell to …

The genome of an organism is under constant attack from exogenous and endogenous DNA
damaging factors such as radiation, carcinogens and reactive radicals. Cells have …

DNA damage checkpoint is one of the surveillance systems to maintain genomic integrity.
Checkpoint systems sense the DNA damage and execute cell cycle arrest through inhibiting …

The DNA damage and replication checkpoints are signaling mechanisms that regulate and
coordinate cellular responses to genotoxic conditions. The activation of checkpoints not only …

Double-strand breaks (DSBs) are the most detrimental form of DNA damage. Failure to
repair these cytotoxic lesions can result in genome rearrangements conducive to the …