Under normal metabolic conditions insulin stimulates microvascular perfusion (capillary
recruitment) of skeletal muscle and subcutaneous adipose tissue and thus increases blood …

Skeletal muscle is an important site for insulin to regulate blood glucose levels. It is
estimated that skeletal muscle is responsible for~ 80% of insulin‐mediated glucose disposal …

Insulin resistance of muscle has been attributed to impairment of elements of insulin
signaling, glucose transport, and/or metabolism within the muscle cells. This article explores …

Insulin has well known metabolic effects. However, depending on the magnitude and
duration of the insulin stimulus, this hormone can also produce vasodilation and vascular …

The vascular system controls the delivery of nutrients and hormones to muscle, and a
number of hormones may act to regulate muscle metabolism and contractile performance by …

Evidence suggests that insulin delivery to skeletal muscle interstitium is the rate-limiting step
in insulin-stimulated muscle glucose uptake and that this process is impaired by insulin …

Conclusion Insulin resistance and Type 2 diabetes are accompanied by a progressive
deterioration of the microcirculation in many tissues. The mechanism behind this association …

Insulin has an exercise-like action to increase microvascular perfusion of skeletal muscle
and thereby enhance delivery of hormone and nutrient to the myocytes. With insulin …

In the 80+ years since insulin's discovery, an enormous amount of literature has
accumulated relating to its actions on body fat, glucose and protein metabolism. In particular …

Insulin resistance plays a key role in the development of type 2 diabetes. Skeletal muscle is
the major storage site for glucose following a meal and as such has a key role in …