Tissue engineered tendons and ligaments

CA Vacanti, YL Cao, RS Langer, JP Vacanti… - US Patent …, 2000 - Google Patents
Connective tissue, including neo-tendons and ligaments, has been constructed using
biodegradable Synthetic Scaf folds seeded with tenocytes. The scaffolds are preferably …

Injury and repair of tendons and ligaments

J Hyman, SA Rodeo - Physical medicine and rehabilitation clinics of North …, 2000 - Elsevier
Tendons and ligaments are fibrous connective tissues that facilitate stability and motion of
joints. Significant dysfunction and disability may result from suboptimal healing of tendon …

Decellularized and engineered tendons as biological substitutes: a critical review

AB Lovati, M Bottagisio, M Moretti - Stem cells international, 2016 - Wiley Online Library
Tendon ruptures are a great burden in clinics. Finding a proper graft material as a substitute
for tendon repair is one of the main challenges in orthopaedics, for which the requirement of …

[HTML][HTML] Biodegradable synthetic scaffolds for tendon regeneration

E Reverchon, L Baldino, S Cardea… - Muscles, ligaments and …, 2012 - ncbi.nlm.nih.gov
Tissue regeneration is aimed at producing biological or synthetic scaffolds to be implanted
in the body for regenerate functional tissues. Several techniques and materials have been …

Ligament tissue engineering: an evolutionary materials science approach

CT Laurencin, JW Freeman - Biomaterials, 2005 - Elsevier
The anterior cruciate ligament (ACL) is important for knee stabilization. Unfortunately, it is
also the most commonly injured intra-articular ligament. Due to poor vascularization, the …

Scaffolds for tendon and ligament repair: review of the efficacy of commercial products

J Chen, J Xu, A Wang, M Zheng - Expert review of medical devices, 2009 - Taylor & Francis
Driven by market demand, many biological and synthetic scaffolds have been developed
during the last 15 years. Both positive and negative results have been reported in clinical …

Multilayered polycaprolactone/gelatin fiber-hydrogel composite for tendon tissue engineering

G Yang, H Lin, BB Rothrauff, S Yu, RS Tuan - Acta biomaterialia, 2016 - Elsevier
Regeneration of injured tendon and ligament (T&L) remains a clinical challenge due to their
poor intrinsic healing capacity. Tissue engineering provides a promising alternative …

Biomechanics of tendon injury and repair

TW Lin, L Cardenas, LJ Soslowsky - Journal of biomechanics, 2004 - Elsevier
Many clinical and experimental studies have investigated how tendons repair in response to
an injury. This body of work has led to a greater understanding of tendon healing …

Tendon augmentation grafts: a systematic review

UG Longo, A Lamberti, N Maffulli… - British medical …, 2010 - academic.oup.com
Introduction Several biomaterials are available to bridge large tendon defects or reinforce
tenuous tendon repairs. Methods We performed a comprehensive search of PubMed …

The use of mesenchymal stem cells in collagen-based scaffolds for tissue-engineered repair of tendons

DL Butler, C Gooch, KRC Kinneberg, GP Boivin… - Nature protocols, 2010 - nature.com
Tendon and ligament injuries are significant contributors to musculoskeletal injuries.
Unfortunately, traditional methods of repair are not uniformly successful and can require …