[PDF] springer.com

Selective inhibitors of nuclear export (SINE) in hematological malignancies

A Das, G Wei, K Parikh, D Liu - Experimental hematology & oncology, 2015 - Springer
Regulated nucleo-cytoplasmic transport plays a major role in maintaining cellular
homeostasis. CRM1 (chromosome region maintenance 1 or exportin 1 or XPO 1) is …
被引用次数：66 相关文章 所有 13 个版本
[PDF] springer.com

SINE (selective inhibitor of nuclear export)–translational science in a new class of anti-cancer agents

J Gerecitano - Journal of hematology & oncology, 2014 - Springer
Regulation of protein trafficking between the nucleus and cytoplasm represents a novel
control point for antineoplastic intervention. Several proteins involved with cellular growth …
被引用次数：35 相关文章 所有 11 个版本
[PDF] springer.com

Selective inhibitors of nuclear export (SINE)–a novel class of anti-cancer agents

K Parikh, S Cang, A Sekhri, D Liu - Journal of hematology & oncology, 2014 - Springer
Dysregulation of the nucleo-cytoplasmic transport of proteins plays an important role in
carcinogenesis. The nuclear export of proteins depends on the activity of transport proteins …
被引用次数：151 相关文章 所有 16 个版本
[HTML] nih.gov

[HTML][HTML] The past, present, and future of CRM1/XPO1 inhibitors

AY Wang, H Liu - Stem cell investigation, 2019 - ncbi.nlm.nih.gov
Therapies targeted at inhibiting nucleo-cytoplasmic transport have found broad applications
in the field of oncology. Chromosome region maintenance 1 (CRM1), better known as …
被引用次数：107 相关文章 所有 6 个版本
[HTML] nih.gov

Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein

J Ishizawa, K Kojima, N Hail Jr, Y Tabe… - Pharmacology & …, 2015 - Elsevier
Nucleocytoplasmic trafficking of proteins/RNAs is essential to normal cellular function.
Indeed, accumulating evidence suggests that cancer cells escape anti-neoplastic …
被引用次数：132 相关文章 所有 8 个版本

Selinexor, selective inhibitor of nuclear export: Unselective bullet for blood cancers

K Benkova, J Mihalyova, R Hajek, T Jelinek - Blood Reviews, 2021 - Elsevier
Abstract Exportin 1 (XPO1), also known as chromosome maintenance 1 protein (CRM1), is
the main transporter for hundreds of proteins like tumor suppressors, growth regulatory …
被引用次数：19 相关文章 所有 4 个版本
[HTML] nih.gov

[HTML][HTML] Heterozygous mutation of cysteine528 in XPO1 is sufficient for resistance to selective inhibitors of nuclear export

JE Neggers, E Vanstreels, E Baloglu, S Shacham… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Exportin-1 (CRM1/XPO1) is a crucial nuclear export protein that transports a wide
variety of proteins from the nucleus to the cytoplasm. These cargo proteins include tumor …
被引用次数：31 相关文章 所有 11 个版本
[PDF] nature.com

Inhibiting cancer cell hallmark features through nuclear export inhibition

Q Sun, X Chen, Q Zhou, E Burstein, S Yang… - Signal transduction and …, 2016 - nature.com
Treating cancer through inhibition of nuclear export is one of the best examples of basic
research translation into clinical application. Nuclear export factor chromosomal region …
被引用次数：123 相关文章 所有 7 个版本

Selective inhibitors of nuclear export in the treatment of hematologic malignancies

A Allegra, V Innao, AG Allegra, R Leanza… - … Lymphoma Myeloma and …, 2019 - Elsevier
The correct localization of molecules between nucleus and cytoplasm is fundamental for
cellular homeostasis and is controlled by a bidirectional transport system. Exportin 1 (XPO1) …
被引用次数：15 相关文章 所有 5 个版本
[HTML] sciencedirect.com

Phase I trial of selinexor (KPT-330), a first-in-class oral selective inhibitor of nuclear export (SINE) in patients (pts) with advanced acute myelogenous leukemia (AML)

M Savona, R Garzon, PN Brown, K Yee, JE Lancet… - 2013 - ashpublications.org
Background AML cells overexpress the nuclear exporter, Exportin 1 (XPO1/CRM1) and
higher XPO1 levels correlate with poor outcome. The novel selective inhibitor of nuclear …
被引用次数：39 相关文章 所有 3 个版本