Tandem repeats are common features of both prokaryote and eukaryote genomes, where
they can be found not only in intergenic regions but also in both the noncoding and coding …

Accumulating evidence suggests that many classes of DNA repeats exhibit attributes that
distinguish them from other genetic variants, including the fact that they are more liable to …

Expansions of simple tandem repeats are responsible for almost 50 human diseases, the
majority of which are severe, degenerative, and not currently treatable or preventable. In this …

Within the closing decade of the twentieth century, 14 neurological disorders were shown to
result from the expansion of unstable trinucleotide repeats, establishing this once unique …

The pathological expansion of unstable trinucleotide repeats currently is known to cause 14
neurological diseases. Over the past several years, researchers have concentrated on the …

Over a third of the human genome is comprised of repetitive sequences, including more than
a million short tandem repeats (STRs). While studies of the pathologic consequences of …

The repeat expansion diseases are genetic disorders caused by intergenerational
expansions of a specific tandem DNA repeat. These disorders range from mildly to severely …

Tandem repeats represent one of the most abundant class of variations in human genomes,
which are polymorphic by nature and become highly unstable in a length-dependent …

Within the last 6–8 years, the remarkable revelation that many neurodegenerative diseases
are caused by the expansion of triplet repeats has prompted a great deal of research …

Repeat sequences in complex genomes have had a checkered history. Before the
introduction of recombinant DNA technology they were one of the few accessible and …