Curcumin and gemcitabine in patients with advanced pancreatic cancer

R Epelbaum, M Schaffer, B Vizel, V Badmaev… - Nutrition and …, 2010 - Taylor & Francis
Curcumin has a potent antiproliferative activity and can also potentiate the antitumor effect of
gemcitabine. This study was undertaken to evaluate the activity and feasibility of …

A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer

M Kanai, K Yoshimura, M Asada, A Imaizumi… - Cancer chemotherapy …, 2011 - Springer
Purpose Curcumin, a plant-derived natural polyphenol, could be a promising anti-cancer
drug and shows synergic effects with cytotoxic agents. We evaluated the safety and …

Phase II trial of curcumin in patients with advanced pancreatic cancer

N Dhillon, BB Aggarwal, RA Newman, RA Wolff… - Clinical cancer …, 2008 - AACR
Purpose: Pancreatic cancer is almost always lethal, and the only US Food and Drug
Administration–approved therapies for it, gemcitabine and erlotinib, produce objective …

Curcumin anticancer studies in pancreatic cancer

S Bimonte, A Barbieri, M Leongito, M Piccirillo… - Nutrients, 2016 - mdpi.com
Pancreatic cancer (PC) is one of the deadliest cancers worldwide. Surgical resection
remains the only curative therapeutic treatment for this disease, although only the minority of …

[HTML][HTML] Therapeutic applications of curcumin for patients with pancreatic cancer

M Kanai - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
A number of preclinical studies have demonstrated anticancer effects for curcumin in various
types of tumors, including pancreatic cancer. Curcumin has anticancer effects both alone …

[PDF][PDF] The dark side of curcumin

E Burgos‐Morón, JM Calderón‐Montaño… - International journal of …, 2010 - Citeseer
Dear Editor, Curcumin is a yellow–orange pigment obtained from the plant Curcuma longa.
The powdered rhizome of this plant, called turmeric, is a common ingredient in curry …

Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine: Results of a prospective …

D Pastorelli, ASC Fabricio, P Giovanis… - Pharmacological …, 2018 - Elsevier
A large body of biomedical evidence indicates that activation of Nrf2 by curcumin increases
the nucleophilic tone and damps inflammation cumulatively supporting the malignant …

Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications

G Bar-Sela, R Epelbaum… - Current medicinal …, 2010 - ingentaconnect.com
Curcumin, commonly called diferuloyl methane, is a hydrophobic polyphenol derived from
rhizome (turmeric) of the herb Curcuma longa. Extensive research over the last half century …

Curcumin analogs: Their roles in pancreatic cancer growth and metastasis

GP Nagaraju, L Benton, SR Bethi… - … Journal of Cancer, 2019 - Wiley Online Library
Curcumin is a polyphenolic constituent of turmeric that is known to have various molecular
effects in preclinical models, leading to prevention and anticancer properties. In clinical …

Synergistic effect of garcinol and curcumin on antiproliferative and apoptotic activity in pancreatic cancer cells

MA Parasramka, SV Gupta - Journal of oncology, 2012 - Wiley Online Library
Pancreatic cancer (PaCa) is a major health concern due to its aggressiveness and early
metastasis. Current treatments for PaCa are limited by development of resistance against …