Genome characterization of a uropathogenic Pseudomonas aeruginosa isolate PA_HN002 with cyclic di-GMP-dependent hyper-biofilm production

S Lin, S Chen, L Li, H Cao, T Li, M Hu, L Liao… - Frontiers in Cellular …, 2022 - frontiersin.org
Pseudomonas aeruginosa can cause various types of infections and is one of the most
ubiquitous antibiotic-resistant pathogens found in healthcare settings. It is capable of …

rpoS-mutation variants are selected in Pseudomonas aeruginosa biofilms under imipenem pressure

X Duan, Y Pan, Z Cai, Y Liu, Y Zhang, M Liu, Y Liu… - Cell & bioscience, 2021 - Springer
Background Pseudomonas aeruginosa is a notorious opportunistic pathogen causing
various types of biofilm-related infections. Biofilm formation is a unique microbial strategy …

Cyclic di-GMP signaling contributes to Pseudomonas aeruginosa-mediated catheter-associated urinary tract infection

SJ Cole, VT Lee - Journal of bacteriology, 2016 - Am Soc Microbiol
ABSTRACT Bis-(3′-5′) cyclic dimeric GMP (c-di-GMP) controls the lifestyle transition
between the sessile and motile states in many Gram-negative bacteria, including the …

Diguanylate Cyclases and Phosphodiesterases Required for Basal-Level c-di-GMP in Pseudomonas aeruginosa as Revealed by Systematic Phylogenetic and …

Q Wei, S Leclercq, P Bhasme, A Xu, B Zhu… - Applied and …, 2019 - Am Soc Microbiol
Cyclic diguanosine monophosphate (c-di-GMP) is an important second messenger involved
in bacterial switching from motile to sessile lifestyles. In the opportunistic pathogen …

Phenotypic and integrated analysis of a comprehensive Pseudomonas aeruginosa PAO1 library of mutants lacking cyclic-di-GMP-related genes

K Eilers, J Kuok Hoong Yam, R Morton… - Frontiers in …, 2022 - frontiersin.org
Pseudomonas aeruginosa is a Gram-negative bacterium that is able to survive and adapt in
a multitude of niches as well as thrive within many different hosts. This versatility lies within …

Modulation of Pseudomonas aeruginosa Biofilm Dispersal by a Cyclic-Di-GMP Phosphodiesterase with a Putative Hypoxia-Sensing Domain

S An, J Wu, LH Zhang - Applied and environmental microbiology, 2010 - Am Soc Microbiol
Pseudomonas aeruginosa encodes many enzymes that are potentially associated with the
synthesis or degradation of the widely conserved second messenger cyclic-di-GMP (c-di …

The c-di-GMP phosphodiesterase PipA (PA0285) regulates autoaggregation and Pf4 bacteriophage production in Pseudomonas aeruginosa PAO1

YM Cai, KW Yu, JH Liu, Z Cai, ZH Zhou… - Applied and …, 2022 - Am Soc Microbiol
In Pseudomonas aeruginosa PAO1, 41 genes encode proteins predicted to be involved in
the production or degradation of c-di-GMP, a ubiquitous secondary messenger that …

Differential impact on motility and biofilm dispersal of closely related phosphodiesterases in Pseudomonas aeruginosa

Y Cai, A Hutchin, J Craddock, MA Walsh, JS Webb… - Scientific reports, 2020 - nature.com
In Pseudomonas aeruginosa, the transition between planktonic and biofilm lifestyles is
modulated by the intracellular secondary messenger cyclic dimeric-GMP (c-di-GMP) in …

Whole-genome sequence, functional annotation, and comparative genomics of the high biofilm-producing multidrug-resistant Pseudomonas aeruginosa MZ4A …

Z Nain, MM Karim - Gene Reports, 2021 - Elsevier
Being an opportunistic pathogen, Pseudomonas aeruginosa causes a wide-array of
nosocomial infections, especially in immune-compromised patients. Therefore, the genomic …

Reduced Intracellular c-di-GMP Content Increases Expression of Quorum Sensing-Regulated Genes in Pseudomonas aeruginosa

S Lin Chua, Y Liu, Y Li, H Jun Ting, GS Kohli… - Frontiers in cellular …, 2017 - frontiersin.org
Cyclic-di-GMP (c-di-GMP) is an intracellular secondary messenger which controls the biofilm
life cycle in many bacterial species. High intracellular c-di-GMP content enhances biofilm …