T lymphocyte death is essential for proper function of the immune system. During the decline
of an immune response, most of the activated T cells die. Cell death is also responsible for …

▪ Abstract Apoptosis of mature T lymphocytes preserves peripheral homeostasis and
tolerance by countering the profound changes in the number and types of T cells stimulated …

Apoptosis plays an essential role in T cell biology. Thymocytes expressing nonfunctional or
autoreactive TCRs are eliminated by apoptosis during development. Apoptosis also leads to …

Publisher Summary This chapter focuses on the genetic and molecular mechanisms of T
lymphocyte apoptosis and also deals with the various phases of apoptosis initiation …

It has been almost three decades since the term “apoptosis” was first coined to describe a
unique form of cell death that involves orderly, gene-dependent cell disintegration. It is now …

Death of some cells in the mammalian body is clearly programmed. In the immune system
there are many examples of programmed cell death, during development of lymphocytes as …

Caspases, a family of cysteine proteases, are critical mediators of apoptosis. To address the
importance of caspases in thymocyte development, we have generated transgenic mice that …

Lymphocyte apoptosis is essential for proper function of the immune system. Among other
functions, it is responsible for the homeostasis of immune cells and plays a key role in the …

Apoptosis of T-lymphocytes is a fundamental process regulating antigen receptor repertoire
selection during T cell maturation and homeostasis of the immune system. It also plays a key …

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