Renal fibrosis is the common pathological hallmark of progressive chronic kidney disease
(CKD) with diverse aetiologies. Recent researches have highlighted the critical role of …

Many clinical observations suggest common mediators in the progression of kidney disease
leading to eventual kidney failure. Among them, accumulating evidence emphasizes the role …

Renal fibrosis, particularly tubulointerstitial fibrosis, is the common final outcome of almost
all progressive chronic kidney diseases. Renal fibrosis is also a reliable predictor of …

Capillary rarefaction is a hallmark of fibrotic diseases and results in reduced blood perfusion
and oxygen delivery. In the kidney, tubulointerstitial fibrosis, which leads to the destruction of …

Tissue hypoxia has been proposed as an important factor in the pathophysiology of both
chronic kidney disease (CKD) and acute kidney injury (AKI), initiating and propagating a …

Oxidative stress results from the disruption of the redox system marked by a notable
overproduction of reactive oxygen species. There are four major sources of reactive oxygen …

Chronic kidney disease (CKD) is a major public health issue. At the histological level, renal
fibrosis is the final common pathway of progressive kidney disease irrespective of the initial …

In the kidney, hypoxia contributes to tubulointerstitial fibrosis, but little is known about its
implications for glomerular damage and glomerulosclerosis. Chronic hypoxia was …

Chronic kidney disease (CKD) is a significant worldwide healthcare problem. Regardless of
the initial injury, renal fibrosis is the common final pathway leading to end stage renal …

Renal fibrosis is a failed wound-healing process of the kidney tissue after chronic, sustained
injury, which is a common pathway and pathological marker of virtually every type of chronic …