The year 2015 has seen great progress in the renal fibrosis field, as key studies began to
build a consensus on the importance of epithelial-to-mesenchymal transition, cell cycle …

Chronic kidney disease (CKD) is characterized by an irreversible decrease in kidney
function and induction of various metabolic dysfunctions. Accumulated findings reveal that …

Many types of kidney injury induce inflammation as a protective response. However,
unresolved inflammation promotes progressive renal fibrosis, which can culminate in end …

Tubulointerstitial hypoxia and peritubular capillary rarefaction are typical features of chronic
progressive renal disease. In response to low oxygen supply, hypoxia-inducible factors …

Acute kidney injury and maladaptive tubular repair leading t... : Current Opinion in Nephrology
and Hypertension Acute kidney injury and maladaptive tubular repair leading to renal fibrosis …

Fibrosis of the glomerular and tubulointerstitial compartments is a common feature of chronic
kidney disease leading to end-stage renal failure. This fibrotic process involves a number of …

Hypoxia‐induced extracellular matrix (ECM) deposition is an important cause of renal
fibrosis that is triggered by unknown mechanisms. Human epididymis secretory protein 4 …

Loss of glomerular function associated with the presence of tubulointerstitial lesions, which
are characterized by peritubular capillary loss, is a common finding in progressive renal …

Recent clinical and animal studies have shown that acute kidney injury (AKI), even if
followed by complete recovery of renal function, can eventually result in chronic kidney …

Endoplasmic reticulum (ER) stress-associated apoptosis plays a role in organ remodeling
after insult. The effect of ER stress on renal tubular damage and fibrosis remains …