Renal fibrosis is a common irreversible process of chronic kidney disease (CKD)
characterized by uncontrolled deposits of extracellular matrix, replacement of cellular …

Renal fibrosis is the principal process underlying the progression of chronic kidney disease
(CKD) to endstage renal disease (ESRD). It is a relatively uniform response involving …

Obstructive nephropathy is a major cause of renal failure, particularly in infants and children.
Cellular and molecular mechanisms responsible for the progression of the tubular atrophy …

Introduction The current therapeutic armamentarium to prevent chronic kidney disease
(CKD) progression is limited to the control of blood pressure and in diabetic patients, the …

Accumulating evidence suggests that dysregulation of hypoxia-regulated transcriptional
mechanisms is involved in development of chronic kidney diseases (CKD). However, it …

The extracellular matrix (ECM) is a complex three-dimensional network of proteins
surrounding cells, forming a niche that controls cell adhesion, proliferation, migration and …

Role of hypoxia in the pathogenesis of renal disease The kidney shows a remarkable
discrepancy between blood supply and oxygenation. Despite high blood flow and oxygen …

Renal hypoxia contributes to chronic kidney disease (CKD) progression, as validated in
experimental and human CKD. In the early stages, increased oxygen consumption causes …

Renal fibrosis is the common end point of virtually all progressive kidney diseases. Renal
fibrosis should not be viewed as a simple and uniform'scar', but rather as a dynamic system …

The concept of reversing chronic kidney disease (CKD) has been intensively researched
over the past decade. Indeed, as the prevalence of end-stage renal disease is constantly on …