Sphingolipids represent a major class of lipids in which selected family members act as
bioactive molecules that control diverse cellular processes, such as proliferation …

In this study, we determined whether minocycline may protect rat cortical cultures against
neurotoxicity induced by sphingomyelinase/ceramide and explored the underlying …

In the last decades, emerging molecular targets for ischemic neuroprotection and
regeneration have been postulated. This fact allowed that classical drugs with well …

Stroke is a group of diseases resulting from cerebral vascular rupture or obstruction and
subsequent brain blood circulation disorder, leading to rapid neurological deficits. Ischemic …

Multiple sclerosis (MS) is the most common human demyelinating disease of the central
nervous system where oxidative stress has been proposed to play an important role in …

Neurotoxicity induced by 6-hydroxydopamine (6-OHDA) is believed to be due, in part, to the
production of reactive oxygen species (ROS). Anti-oxidants by inhibiting free radical …

Remarkable progress has been made during the past decade in our understanding of
mechanisms of cell death in neurodegenerative disorders such as Parkinson's disease (PD) …

Minocycline, a semisynthetic tetracycline-derived antibiotic, has been shown to exert anti-
apoptotic, anti-inflammatory, and antioxidant effects. Furthermore, there is rapidly growing …

The neuroprotective effects of minocycline–which is broadly protective in neurologic-disease
models featuring cell death and is being evaluated in clinical trials–were investigated both in …

In this review we explore and integrate the knowledge of the plausible pharmacological
targets that could explain the new application for the well known semi-synthetic, tetracycline …