Perifosine is an Akt inhibitor displaying strong antineoplastic effects in human tumor cell
lines and is currently being tested in phase II clinical trials for treatment of major human …

The serine/threonine kinase Akt, a downstream effector of phosphatidylinositol 3-kinase
(PI3K), is known to play an important role in antiapoptotic signaling and has been implicated …

Hepatocellular carcinoma (HCC) is one of the most common solid cancers, representing the
third cause of cancer-related death among cirrhotic patients. Treatment of advanced HCC …

The Akt inhibitor, perifosine, is an alkylphospholipid exhibiting antitumor properties and is
currently in phase II clinical trials for various types of cancer. The mechanisms by which …

A significant impediment to the success of cancer chemotherapy is the occurrence of
multidrug resistance, which, in many cases, is attributable to overexpression of membrane …

Perifosine treatment exhibits a complex molecular response including the inhibition of Akt or
the induction of apoptosis via clustering of death receptors in lipid rafts. However, the …

Purpose We analyzed the anti-tumor effect and the mechanism of action of perifosine, an
orally active alkylphospholipid AKT inhibitor using in vitro models of human ovarian cancer …

OBJECTIVE: Triptolide has shown antitumor activity in a broad range of solid tumors and on
leukemic cells in vitro. MATERIALS AND METHODS: The THP1 cell line and primary acute …

Abstract The PI3K/Akt/mTOR pathway is aberrantly active in most human cancers and
contributes to cell growth, proliferation, and survival. Akt is a nodal regulator of cellular …

Perifosine is a synthetic novel alkylphospholipid, a new class of antitumor agents which
targets cell membranes and inhibits Akt activation. Here we show that baseline …