Efficacy of epidermal growth factor receptor targeting in advanced chordoma: case report and literature review

SG Launay, B Chetaille, F Medina, D Perrot… - BMC cancer, 2011 - Springer
Background Chordomas are very rare low-grade malignant bone tumors that arise from the
embryonic rests of the notochord. They are characterized by slow growth and long history …

Durable response of spinal chordoma to combined inhibition of IGF-1R and EGFR

T Aleksic, L Browning, M Woodward, R Phillips… - Frontiers in …, 2016 - frontiersin.org
Chordomas are rare primary malignant bone tumors arising from embryonal notochord
remnants of the axial skeleton. Chordomas commonly recur following surgery and …

[HTML][HTML] Sustained response of a clivus chordoma to erlotinib after imatinib failure

A Houessinon, M Boone, JM Constans… - Case Reports in …, 2015 - karger.com
Chordoma is a rare malignant axial tumour that develops from embryonic remnants of the
notochord. Surgery and irradiation are the standard initial treatment. However, local …

[HTML][HTML] Chordoma: a case report and review of literature

A Noor, P Bindal, M Ramirez… - The American journal of …, 2020 - ncbi.nlm.nih.gov
Objective: Unusual or unexpected effect of treatment Background: Chordoma is rare, but
aggressive bone tumor, primarily affecting the axial skeleton. Systemic chemotherapies are …

Afatinib is a new therapeutic approach in chordoma with a unique ability to target EGFR and brachyury

P Magnaghi, B Salom, L Cozzi, N Amboldi… - Molecular cancer …, 2018 - AACR
Chordomas are rare bone tumors with no approved therapy. These tumors express several
activated tyrosine kinase receptors, which prompted attempts to treat patients with tyrosine …

Efficacy of pazopanib and sunitinib in advanced axial chordoma: a single reference centre case series

A Lipplaa, S Dijkstra, H Gelderblom - Clinical Sarcoma Research, 2016 - Springer
Background Chordomas are rare malignant tumours of the axial skeleton and skull base
supposed to arise from cellular remnants of the notochord. These tumours have the potential …

Chordoma: a case series and review of the literature

O Alan, T Akin Telli, O Ercelep… - Journal of Medical Case …, 2018 - Springer
Background Chordoma is a rare malignant tumor of the skull base and axial skeleton, with
an incidence of less than 0.1/100,000 per year. Patients with advanced chordoma have a …

Response to erlotinib in a patient with treatment refractory chordoma

N Singhal, D Kotasek, FX Parnis - Anti-Cancer Drugs, 2009 - journals.lww.com
Chordomas are rare tumors arising from the axial skeleton. The disease is characterized by
slow local growth, frequent local recurrences, and rare systemic spread. Surgery and local …

Erlotinib inhibits growth of a patient-derived chordoma xenograft

IM Siu, J Ruzevick, Q Zhao, N Connis, Y Jiao… - PLoS …, 2013 - journals.plos.org
Chordomas are rare primary bone tumors that occur along the neuraxis. Primary treatment is
surgery, often followed by radiotherapy. Treatment options for patients with recurrence are …

Molecular targeted therapies in advanced or metastatic chordoma patients: facts and hypotheses

L Lebellec, S Aubert, F Zaïri, T Ryckewaert… - Critical Reviews in …, 2015 - Elsevier
Chordomas, derived from undifferentiated notochordal remnants, represent less than 4% of
bone primary tumors. Despite surgery followed by radiotherapy, local and metastatic …