Intermedilysin Is Essential for the Invasion of Hepatoma HepG2 Cells by Streptococcus intermedius

A Sukeno, H Nagamune, RA Whiley… - Microbiology and …, 2005 - Wiley Online Library
Streptococcus intermedius causes endogenous infections leading to abscesses. This
species produces intermedilysin (ILY), a human‐specific cytolysin. Because of the significant …

Distribution of the intermedilysin gene among the anginosus group streptococci and correlation between intermedilysin production and deep-seated infection with …

H Nagamune, RA Whiley, T Goto, Y Inai… - Journal of clinical …, 2000 - Am Soc Microbiol
The distribution of intermedilysin, a human-specific cytolysin, among the anginosus group
streptococci and the correlation of toxin production and infection by Streptococcus …

Effect on Polymorphonuclear Cell Function of a Human-Specific Cytotoxin, Intermedilysin, Expressed byStreptococcus intermedius

MG Macey, RA Whiley, L Miller… - Infection and …, 2001 - Am Soc Microbiol
Streptococcus intermedius is a member of the normal flora of the mouth but is also an
opportunistic pathogen associated with purulent infections at oral and nonoral sites …

LacR mutations are frequently observed in Streptococcus intermedius and are responsible for increased intermedilysin production and virulence

T Tomoyasu, H Imaki, S Masuda, A Okamoto… - Infection and …, 2013 - Am Soc Microbiol
Streptococcus intermedius secretes a human-specific cytolysin, intermedilysin (ILY), which is
considered to be the major virulence factor of this pathogen. We screened for a repressor of …

Intermedilysin: A Cytolytic Toxin Specific for Human Cells of a Streptococcus intermedius Isolated from Human Liver Abscess

H Nagamune, C Ohnishi, A Katsuura, Y Taoka… - Streptococci and the …, 1997 - Springer
Streptococcus intermedius is one of the three distinct species classified into the
Streptococcus milleri-group (SMG, S. anginosus, S. constellatus and S. intermedius) which …

Role of Catabolite Control Protein A in the Regulation of Intermedilysin Production by Streptococcus intermedius

T Tomoyasu, A Tabata, R Hiroshima, H Imaki… - Infection and …, 2010 - Am Soc Microbiol
Streptococcus intermedius is an opportunistic pathogen of humans that causes purulent
infections, including brain and liver abscesses. This pathogen secretes a human-specific …

Intermedilysin, a novel cytotoxin specific for human cells secreted by Streptococcus intermedius UNS46 isolated from a human liver abscess

H Nagamune, C Ohnishi, A Katsuura… - Infection and …, 1996 - Am Soc Microbiol
A novel cytotoxin (intermedilysin) specific for human cells was identified as a cytolytic factor
of Streptococcus intermedius UNS46 isolated from a human liver abscess. Intermedilysin …

Expression and Functional Properties of theStreptococcus intermedius Surface Protein Antigen I/II

FC Petersen, S Pasco, J Ogier, JP Klein… - Infection and …, 2001 - Am Soc Microbiol
Streptococcus intermedius is associated with deep-seated purulent infections. In this study,
we investigated expression and functional activities of antigen I/II in S. intermedius. The S …

[HTML][HTML] Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator …

TR Hughes, KS Ross, GJM Cowan, B Sivasankar… - Molecular …, 2009 - Elsevier
The unique species specificity of the bacterial cytolysin intermedilysin is explained by its
requirement for the human complement regulator CD59 as the primary receptor. Binding …

Characterization of the C-terminal domains of intimin-like proteins of enteropathogenic and enterohemorrhagic Escherichia coli, Citrobacter freundii, and Hafnia alvei

G Frankel, DC Candy, P Everest… - Infection and …, 1994 - Am Soc Microbiol
Surface proteins called intimins (Int), which are homologous to the invasin protein (Inv) of
Yersinia spp., play a role in inducing brush border damage, termed attachment and …