Lipid peroxidation facilitates aluminum accumulation in rat brain synaptosomes

FC Amador, MS Santos, CR Oliveira - Journal of Toxicology and …, 1999 - Taylor & Francis
Aluminum, a metal without redox capacity in biological systems, potentiates the stimulation
of lipid peroxidation induced by Fe2+. In this study the interactions between aluminum and …

A model of aluminum exposure associated with lipid peroxidation in rat brain

Y Ogasawara, E Ohata, T Sakamoto, K Ishii… - Biological trace element …, 2003 - Springer
We have developed a rat model to investigate the relationship between aluminum exposure
and aluminum accumulation, and with oxidative damage in brain tissues. Intraperitoneal …

Aluminum-induced degeneration of astrocytes occurs via apoptosis and results in neuronal death

MB Suárez-Fernández, AB Soldado, A Sanz-Medel… - Brain research, 1999 - Elsevier
The mechanisms by which aluminum interacts with the nervous system are only partly
understood. In this study, we used cultured astrocytes and neurons to investigate the effects …

[HTML][HTML] Preclinical evidences of aluminum-induced neurotoxicity in hippocampus and pre-frontal cortex of rats exposed to low doses

RM Fernandes, MG Corrêa, WAB Aragão… - Ecotoxicology and …, 2020 - Elsevier
Aluminum (Al) is a neurotoxicant agent implicated in several behavioral, neuropathological
and neurochemical changes associated with cognitive impairments. Nevertheless …

Chronic oral exposure of aluminum chloride in rat modulates molecular and functional neurotoxic markers relevant to Alzheimer's disease

M Dey, RK Singh - Toxicology Mechanisms and Methods, 2022 - Taylor & Francis
Aluminum is an environmentally abundant potential neurotoxic agent that may result in
oxidative damage to a range of cellular biomarkers. The potential sources of aluminum …

Aluminum has both oxidant and antioxidant effects in mouse brain membranes

PI Oteiza, CG Fraga, CL Keen - Archives of biochemistry and biophysics, 1993 - Elsevier
The in vitro effects of aluminum (A1) on lipid peroxidation were studied in mouse brain
homogenates and purified brain subcellular fractions. In brain homogenates prepared in 5 …

Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease

J Savory, MM Herman, O Ghribi - Journal of Alzheimer's …, 2006 - content.iospress.com
For four decades the controversial question concerning a possible role for aluminum
neurotoxicity in contributing to the pathogenesis of Alzheimer's disease has been debated …

Aluminum toxicity and oxidative stress

RM Fernandes, LG Eiró, V dos Santos Chemelo… - Toxicology, 2021 - Elsevier
Aluminum is present in everyday life in several ways since it has high strength, ductility, and
ability to conduct energy and heat. This metal is the third most abundant in the earth's crust …

Aluminum maltolate-induced toxicity in NT2 cells occurs through apoptosis and includes cytochrome c release

KJS Griffioen, O Ghribi, N Fox, J Savory, DA DeWitt - Neurotoxicology, 2004 - Elsevier
Aluminum (Al) compounds are neurotoxic and have been shown to induce experimental
neurodegeneration although the mechanism of this effect is unclear. In order to study this …

Ligand specific effects on aluminum incorporation and toxicity in neurons and astrocytes

L Lévesque, CA Mizzen, DR McLachlan, PE Fraser - Brain research, 2000 - Elsevier
Aluminum is present in many manufactured foods and medicines and is added to drinking
water for purification purposes. It has been proposed that aluminum is a contributing factors …