Physical inactivity has recently been identified as a major and independent risk factor for the
development of dementia and cognitive decline. In addition to the effect of exercise with …

Chronic inflammation is involved in the pathogenesis of insulin resistance, atherosclerosis,
neurodegeneration, and tumour growth. Regular exercise offers protection against type 2 …

Type 2 diabetes, cardiovascular diseases, colon cancer, breast cancer, dementia and
depression constitute a cluster of diseases, which defines 'a diseasome of physical …

Exercise has beneficial effects in ameliorating metabolic disorders, and a combined
therapeutic regimen of regular exercise and pharmaceutical treatment is often …

Physical activity decreases the risk of a network of diseases, and exercise may be
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …

In the past, the role of physical activity as a life-style modulating factor has been considered
as that of a tool to balance energy intake. Although it is important to avoid obesity, physical …

Exercise stimulates the release of proteins with autocrine, paracrine, or endocrine functions
produced in skeletal muscle, termed myokines. Based on the current state of knowledge, the …

Myokines are muscle‐derived cytokines and chemokines that act extensively on organs and
exert beneficial metabolic functions in the whole‐body through specific signal networks …

Physical exercise has beneficial effects on metabolic diseases, and a combined therapeutic
regimen of regular exercise and pharmaceutical treatment is often recommended for their …

Highlights•Skeletal muscle secretes myokines that exert autocrine paracrine and endocrine
effects.•Paracrine factors modulate muscle angiogenesis, adipogenesis, and …