Galanin–25 years with a multitalented neuropeptide: Galanin and spinal pain mechanisms: Where do we stand in 2008?

XJ Xu, T Hökfelt, Z Wiesenfeld-Hallin - Cellular and Molecular Life …, 2008 - Springer
Since the discovery of galanin in 1983, one of the most frequently mentioned possible
physiological functions for this peptide is spinal pain modulation. This notion, initially based …

Galanin and spinal pain mechanisms: past, present, and future

XJ Xu, T Hökfelt, Z Wiesenfeld-Hallin - Galanin, 2010 - Springer
Since the discovery of galanin in 1983, one of the most frequently suggested physiological
function for this peptide is pain modulation at the level of the spinal cord. This notion, initially …

Galanin and spinal nociceptive mechanisms: recent advances and therapeutic implications

XJ Xu, T Hökfelt, T Bartfai, Z Wiesenfeld-Hallin - Neuropeptides, 2000 - Elsevier
Galanin is a peptide consisting of 29 or 30 (in humans) amino acids that is present in
sensory and spinal dorsal horn neurons. Endogenous galanin may have an important …

A new gal in town: a systematic review of the role of galanin and its receptors in experimental pain

D Fonseca-Rodrigues, A Almeida, F Pinto-Ribeiro - Cells, 2022 - mdpi.com
Galanin is a neuropeptide expressed in a small percentage of sensory neurons of the dorsal
root ganglia and the superficial lamina of the dorsal horn of the spinal cord. In this work, we …

The participation of galanin in pain processing at the spinal level

HX Liu, T Hökfelt - Trends in pharmacological sciences, 2002 - cell.com
Abstract Galanin, a 29-amino-acid peptide expressed in dorsal root ganglia (DRG) and
spinal dorsal horn interneurones, is regulated by nerve injury and peripheral inflammation …

Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors

HX Liu, P Brumovsky, R Schmidt… - Proceedings of the …, 2001 - National Acad Sciences
Galanin is a 29-aa neuropeptide with a complex role in pain processing. Several galanin
receptor subtypes are present in dorsal root ganglia and spinal cord with a differential …

Galanin and spinal nociceptive mechanisms: recent results from transgenic and knock-out models

Z Wiesenfeld-Hallin, XJ Xu, JN Crawley, T Hökfelt - Neuropeptides, 2005 - Elsevier
Genetically modified mice with transgenic overexpression of galanin or depletion of genes
for galanin or galanin receptors have become available, providing a new approach for …

Peripheral galanin receptor 2 as a target for the modulation of pain

RP Hulse, LF Donaldson… - Pain research and …, 2012 - Wiley Online Library
The neuropeptide galanin is widely expressed in the nervous system and has an important
role in nociception. It has been shown that galanin can facilitate and inhibit nociception in a …

Galanin in sensory neurons in the spinal cord.

Z Wiesenfeld-Hallin, T Bartfai… - Frontiers in …, 1992 - europepmc.org
The distribution and physiological effects of the neuropeptide galanin (GAL) have been
examined in the somatosensory system. GAL is normally present in a few sensory neurons …

Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour

TJS Shi, X Hua, X Lu, S Malkmus… - European Journal of …, 2006 - Wiley Online Library
Galanin is a 29‐amino‐acid peptide expressed in dorsal root ganglion (DRG) neurones and
spinal dorsal horn neurones. It affects pain threshold and has developmental and trophic …