Galanin receptors as a potential target for neurological disease
Introduction: Galanin is a 29/30 amino acid long neuropeptide that is widely expressed in
the brains of many mammals. Galanin exerts its biological activities through three different G …
the brains of many mammals. Galanin exerts its biological activities through three different G …
Transgenic overexpression of galanin in the dorsal root ganglia modulates pain-related behavior
FE Holmes, A Bacon, RJP Pope… - Proceedings of the …, 2003 - National Acad Sciences
The neuropeptide galanin is expressed in the dorsal root ganglia (DRG) and spinal cord and
is thought to be involved in the modulation of pain processing. However, its mechanisms of …
is thought to be involved in the modulation of pain processing. However, its mechanisms of …
Galanin Expression in Neuropathic Pain: Friend or Foe?a
MS Ramer, W Ma, PG Murphy… - Annals of the New …, 1998 - Wiley Online Library
We investigated a possible link between galanin expression and evoked pain
accompanying painful partial sciatic nerve lesions. Increased galanin immunoreactivity (IR) …
accompanying painful partial sciatic nerve lesions. Increased galanin immunoreactivity (IR) …
[PDF][PDF] Galanin-25 years with a multitalented neuropeptide
T Hokfelt, K Tatemoto - CMLS-Cellular and Molecular Life Sciences, 2008 - academia.edu
Since its discovery in 1983 galanin has been implicated in many diverse biological roles [1].
It has a widespread distribution throughout both the central (CNS) and peripheral nervous …
It has a widespread distribution throughout both the central (CNS) and peripheral nervous …
Galanin acts as a trophic factor to the central and peripheral nervous systems
SA Hobson, A Bacon, CR Elliot-Hunt, FE Holmes… - Galanin, 2010 - Springer
The neuropeptide galanin is widely, but not ubiquitously, expressed in the adult nervous
system. Its expression is markedly up-regulated in many neuronal tissues after nerve injury …
system. Its expression is markedly up-regulated in many neuronal tissues after nerve injury …
Galanin: a multitalented neuropeptide
T Hökfelt, K Tatemoto - Galanin, 2010 - Springer
Galanin, one of the many (> 100) neuropeptides, was discovered in 1983 based on its C-
terminal amidation motif. Over the years, three more members of the galanin family have …
terminal amidation motif. Over the years, three more members of the galanin family have …
Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity
R Lang, AL Gundlach, FE Holmes, SA Hobson… - Pharmacological …, 2015 - ASPET
Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …
Galanin receptor subtypes and ligand binding
A Florén, T Land, Ü Langel - Neuropeptides, 2000 - Elsevier
Galanin is a neuropeptide initiating its multiple biological effects by binding to different
subtypes of seven transmembrane spanning galanin receptors, thus transducing the …
subtypes of seven transmembrane spanning galanin receptors, thus transducing the …
Generation and phenotypic characterization of a galanin overexpressing mouse
K Holmberg, E Kuteeva, P Brumovsky, U Kahl… - Neuroscience, 2005 - Elsevier
In most parts of the peripheral nervous system galanin is expressed at very low levels. To
further understand the functional role of galanin, a mouse overexpressing galanin under the …
further understand the functional role of galanin, a mouse overexpressing galanin under the …
Cloning and evaluation of the role of rat GALR‐2, a novel subtype of galanin receptor, in the control of pain perception
S Ahmad, D O'DONNELL, K Payza… - Annals of the New …, 1998 - Wiley Online Library
We have identified a novel subtype of galanin receptor (GALR‐2) in rat dorsal root ganglia
and spinal cord. The open reading frame of GALR‐2 is 1116 nucleotides long, encoding a …
and spinal cord. The open reading frame of GALR‐2 is 1116 nucleotides long, encoding a …