Galanin: a novel therapeutic target for depression, anxiety disorders and drug addiction?

A Holmes, MR Picciotto - CNS & Neurological Disorders-Drug …, 2006 - ingentaconnect.com
Galanin is a neuropeptide synthesized in many neuronal types including brainstem
norepinephrine-producing cells of the locus coeruleus and the serotonin-producing neurons …

Galanin expression in adult human dorsal root ganglion neurons: initial observations

M Landry, K Åman, J Dostrovsky, AM Lozano… - Neuroscience, 2003 - Elsevier
Human dorsal root ganglia (DRGs) were obtained during various procedures and processed
for single and double in situ hybridisation using oligonucleotide probes complementary to …

Galanin receptor 1 is expressed in a subpopulation of glutamatergic interneurons in the dorsal horn of the rat spinal cord

M Landry, R Bouali‐Benazzouz… - Journal of …, 2006 - Wiley Online Library
The 29/30 amino acid neuropeptide galanin has been implicated in pain processing at the
spinal level and local dorsal horn neurons expressing the Gal1 receptor may play a critical …

Galanin–25 years with a multitalented neuropeptide: Galanin and the neuroendocrine axes

I Mechenthaler - Cellular and Molecular Life Sciences, 2008 - Springer
Galanin has diverse physiological functions, including nociception, arousal/sleep regulation,
cognition, and many aspects of neuroendocrine activities that are associated with feeding …

Galanin family peptides: Molecular structure, expression and roles in the neuroendocrine axis and in the spinal cord

S Zhu, X Hu, S Bennett, O Charlesworth… - Frontiers in …, 2022 - frontiersin.org
Galanin is a neurohormone as well as a neurotransmitter and plays versatile physiological
roles for the neuroendocrine axis, such as regulating food intake, insulin level and …

[引用][C] Galanin and its receptors: introduction to the Third International Symposium, San Diego, California, USA, 21-22 October 2004

T Hokfelt - Neuropeptides, 2005 - … 1-3 BAXTERS PLACE, LEITH WALK …

Effect of intrathecal galanin and its putative antagonist M35 on pain behavior in a neuropathic pain model

HX Liu, T Hökfelt - Brain research, 2000 - Elsevier
There is currently some debate over a possible role of galanin in pain processing. It was
recently reported that the levels of galanin in dorsal root ganglia (DRGs) seem related to …

Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests

T Bartfai, X Lu, H Badie-Mahdavi… - Proceedings of the …, 2004 - National Acad Sciences
The pharmacological exploitation of the galanin receptors as drug targets for treatment of
epilepsy, depression, and pain has been hampered by the lack of workable compounds for …

The role of galanin as a multi-functional neuropeptide in the nervous system

D Wynick, SWN Thompson, SB McMahon - Current opinion in …, 2001 - Elsevier
The neuropeptide galanin is expressed developmentally in the DRG and is rapidly up-
regulated 120-fold after peripheral nerve section in the adult. The generation and study of …

Central and peripheral expression of galanin in response to inflammation

RR Ji, X Zhang, Q Zhang, Å Dagerlind, S Nilsson… - Neuroscience, 1995 - Elsevier
Using in situ hybridization, immunohistochemistry and receptor binding methodology, the
galanin messenger RNA levels, galanin binding and galanin-like immunoreactivity were …