Galanin receptors and ligands

KEB Webling, J Runesson, T Bartfai… - Frontiers in …, 2012 - frontiersin.org
The neuropeptide galanin was first discovered 30 years ago. Today, the galanin family
consists of galanin, galanin-like peptide (GALP), galanin-message associated peptide …

In vivo and in vitro effects of peripheral galanin on nociceptive transmission in naive and neuropathic states

SJL Flatters, AJ Fox, AH Dickenson - Neuroscience, 2003 - Elsevier
Galanin is widely distributed in the nervous system and is consistently upregulated in both
dorsal root ganglion and spinal neurones by peripheral nerve injury. This study investigates …

The effect of naturally occurring fragments of galanin message-associated peptide on spinal cord excitability in rats

S Andell-Jonsson, IS Xu, T Bartfai, XJ Xu… - Neuroscience …, 1997 - Elsevier
Galanin message-associated peptide (GMAP), a 60 amino acid fragment of galanin
precursor protein, is present in dorsal root ganglion cells and upon intrathecal (it) …

The biological role of galanin in normal and neuropathic states

BJ Kerr, D Wynick, SWN Thompson, SB McMahon - 2000 - Elsevier
Publisher Summary This chapter discusses the biological role of galanin in normal and
neuropathic states. Injuries to peripheral nerves in man are associated with a range of …

Galanin receptor ligands

X Lu, L Lundström, U Langel, T Bartfai - Neuropeptides, 2005 - Elsevier
The three galanin receptor subtypes (GalR1–3) belong to the G protein-coupled receptor
superfamily. The widespread distribution of galanin and its receptors in the CNS and PNS …

Galanin receptor binding sites in adult rat spinal cord respond differentially to neonatal capsaicin, dorsal rhizotomy and peripheral axotomy

S Kar, R Quirion - European Journal of Neuroscience, 1994 - Wiley Online Library
The discrete distribution and possible changes in specific [125I] galanin binding sites were
evaluated in the rat spinal cord following neonatal capsaicin treatment, dorsal rhizotomy and …

Anatomy and physiology of central galanin-containing pathways

I Merchenthaler, FJ López, A Negro-Vilar - Progress in neurobiology, 1993 - Elsevier
Since the discovery of galanin (GAL) in 1983 (Tatemoto et al., 1983) numerous anatomical,
physiological and pharmacological investigations have demonstrated that the peptide is …

Differential galanin upregulation in dorsal root ganglia and spinal cord after graded single ligature nerve constriction of the rat sciatic nerve

MF Coronel, PR Brumovsky, T Hökfelt… - Journal of chemical …, 2008 - Elsevier
Single ligature nerve constriction (SLNC) is a newly developed animal model for the study of
neuropathic pain. SLNC of the rat sciatic nerve induces pain-related behaviors, as well as …

Mice deficient for galanin receptor 2 have decreased neurite outgrowth from adult sensory neurons and impaired pain‐like behaviour

SA Hobson, FE Holmes, NCH Kerr… - Journal of …, 2006 - Wiley Online Library
Expression of the neuropeptide galanin is markedly up‐regulated within the adult dorsal root
ganglia (DRG) following peripheral nerve injury. We have previously demonstrated that …

A novel GalR2-specific peptide agonist

J Runesson, I Saar, L Lundström, J Järv, Ü Langel - Neuropeptides, 2009 - Elsevier
The galanin peptide family and its three receptors have with compelling evidence been
implicated in several high-order physiological disorders. The co-localization with other …