An etiological Foxp2 mutation impairs neuronal gain in layer VI cortico-thalamic cells through increased GABAB/GIRK signaling
M Druart, M Groszer… - Journal of Neuroscience, 2020 - Soc Neuroscience
A rare mutation affecting the Forkhead-box protein P2 (FOXP2) transcription factor causes a
severe monogenic speech and language disorder. Mice carrying an identical point mutation …
severe monogenic speech and language disorder. Mice carrying an identical point mutation …
Sumoylation of FOXP2 regulates motor function and vocal communication through Purkinje cell development
Background Mutations in the gene encoding the transcription factor forkhead box P2
(FOXP2) result in brain developmental abnormalities, including reduced gray matter in both …
(FOXP2) result in brain developmental abnormalities, including reduced gray matter in both …
Foxp2 loss of function increases striatal direct pathway inhibition via increased GABA release
Heterozygous mutations of the Forkhead-box protein 2 (FOXP2) gene in humans cause
childhood apraxia of speech. Loss of Foxp2 in mice is known to affect striatal development …
childhood apraxia of speech. Loss of Foxp2 in mice is known to affect striatal development …
Modified sound-evoked brainstem potentials in Foxp2 mutant mice
Heterozygous mutations of the human FOXP2 gene cause a developmental disorder
involving impaired learning and production of fluent spoken language. Previous …
involving impaired learning and production of fluent spoken language. Previous …
Mice carrying a humanized Foxp2 knock-in allele show region-specific shifts of striatal Foxp2 expression levels
C Schreiweis, T Irinopoulou, B Vieth, L Laddada… - Cortex, 2019 - Elsevier
Genetic and clinical studies of speech and language disorders are providing starting points
to unravel underlying neurobiological mechanisms. The gene encoding the transcription …
to unravel underlying neurobiological mechanisms. The gene encoding the transcription …
Speech- and language-linked FOXP2 mutation targets protein motors in striatal neurons
HY Kuo, SY Chen, RC Huang, H Takahashi, YH Lee… - Brain, 2023 - academic.oup.com
Human speech and language are among the most complex motor and cognitive abilities.
The discovery of a mutation in the transcription factor FOXP2 in KE family members with …
The discovery of a mutation in the transcription factor FOXP2 in KE family members with …
FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis
The expression patterns of the transcription factor FOXP2 in the developing mammalian
forebrain have been described, and some studies have tested the role of this protein in the …
forebrain have been described, and some studies have tested the role of this protein in the …
Ultrasonic vocalization impairment of Foxp2 (R552H) knockin mice related to speech-language disorder and abnormality of Purkinje cells
E Fujita, Y Tanabe, A Shiota, M Ueda… - Proceedings of the …, 2008 - National Acad Sciences
Previous studies have demonstrated that mutation in the forkhead domain of the forkhead
box P2 (FOXP2) protein (R553H) causes speech-language disorders. To further analyze …
box P2 (FOXP2) protein (R553H) causes speech-language disorders. To further analyze …
FOXP2 as a molecular window into speech and language
Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome
characterized by impaired speech development and linguistic deficits. Recent genomic …
characterized by impaired speech development and linguistic deficits. Recent genomic …