Depression is a devastating and prevalent disease, with profound effects on neural structure
and function; however the etiology and neuropathology of depression remain poorly …

It is widely accepted that changes underlying depression and antidepressant‐like effects
involve not only alterations in the levels of neurotransmitters as monoamines and their …

Major depressive disorder has been associated with manifold pathophysiological changes.
These include metabolic abnormalities in discreet brain areas; modifications in the level of …

Major depressive disorder (MDD) is characterized by structural and neurochemical changes
in limbic structures, including the hippocampus, that regulate mood and cognitive functions …

Major depressive disorder (MDD) was previously hypothesized to be a disease of
monoamine deficiency in which low levels of monoamines in the synaptic cleft were …

Depression is a prevalent, highly debilitating mental disorder affecting up to 15% of the
population at least once in their lifetime, with huge costs for society. Neurobiological …

There is a growing body of evidence that neural stem cells reside in the adult central
nervous system where neurogenesis occurs throughout lifespan. Neurogenesis concerns …

Depression is a common chronic psychiatric disorder that is also often co-morbid with
numerous neurological and immune diseases. Accumulating evidence indicates that …

The behavioral changes in depression can relate to alterations in hippocampal function. A
variety of inputs to the hippocampus can effect mood, including norepinephrine (NE) …

Readers of this journal are likely to agree with three statements. First, it is impossible to think
effectively about depression outside the context of biology. Second, it is impossible to think …