Role of group II and group III metabotropic glutamate receptors in spinal cord injury

CD Mills, KM Johnson, CE Hulsebosch - Experimental neurology, 2002 - Elsevier
Spinal cord injury (SCI) produces an increase in extracellular excitatory amino acid (EAA)
concentrations that results in glutamate receptor-mediated excitotoxic events. An important …

Changes in metabotropic glutamate receptor expression following spinal cord injury

CD Mills, SD Fullwood, CE Hulsebosch - Experimental neurology, 2001 - Elsevier
Spinal cord injury (SCI) initiates biochemical events that lead to an increase in extracellular
excitatory amino acid concentrations, resulting in glutamate receptor-mediated excitotoxic …

Group I metabotropic glutamate receptors in spinal cord injury: roles in neuroprotection and the development of chronic central pain

CD Mills, KM Johnson, CE Hulsebosch - Journal of neurotrauma, 2002 - liebertpub.com
Spinal cord injury (SCI) initiates a cascade of biochemical events that leads to an increase in
extracellular excitatory amino acid (EAA) concentrations, which results in glutamate receptor …

Involvement of metabotropic glutamate receptors in excitatory amino acid and GABA release following spinal cord injury in rat

CD Mills, GY Xu, DJ McAdoo… - Journal of …, 2001 - Wiley Online Library
Spinal cord injury (SCI) leads to an increase in extracellular excitatory amino acid (EAA)
concentrations resulting in glutamate receptor‐mediated excitotoxic events. The glutamate …

AIDA reduces glutamate release and attenuates mechanical allodynia after spinal cord injury

CD Mills, GY Xu, KM Johnson, DJ McAdoo… - …, 2000 - journals.lww.com
Spinal cord injury (SCI) leads to an increase in extracellular excitatory amino acid (EAA)
concentrations, resulting in glutamate receptor-mediated excitotoxicity and central …

Role of group I metabotropic glutamate receptors in traumatic spinal cord white matter injury

SK Agrawal, E Theriault, MG Fehlings - Journal of neurotrauma, 1998 - liebertpub.com
Metabotropic glutamate receptors (mGluRs) participate in glutamate neural transmission, but
their role in the pathophysiology of spinal cord injury (SCI) has not been explored …

Upregulation of Group I metabotropic glutamate receptors in neurons and astrocytes in the dorsal horn following spinal cord injury

YS Gwak, CE Hulsebosch - Experimental neurology, 2005 - Elsevier
Of the glutamate receptor types, the metabotropic glutamate receptors (mGluRs) are G
proteins coupled and can initiate a number of intracellular pathways leading to …

Spinal axonal injury transiently elevates the level of metabotropic glutamate receptor 5, but not 1, in cord-projection central neurons

YJ Wang, GF Tseng - Journal of neurotrauma, 2004 - liebertpub.com
In investigating the effect of spinal injury on cord-projection central neurons, we found that
rat rubrospinal neurons retained glutamatergic afferents and, in general, ionotropic …

Increased expression of metabotropic glutamate receptor subtype 1 on spinothalamic tract neurons following spinal cord injury in the rat

CD Mills, CE Hulsebosch - Neuroscience letters, 2002 - Elsevier
Spinal cord injury (SCI) leads to an increase in metabotropic glutamate receptor subtype 1
(mGluR1) immunoreactivity in the peri-lesion area. The increased expression of mGluR1 …

Behavioural evidence supporting a differential role for group I and II metabotropic glutamate receptors in spinal nociceptive transmission

S Dolan, AM Nolan - Neuropharmacology, 2000 - Elsevier
Metabotropic glutamate receptors (mGluRs) have been shown to contribute to nociceptive
processing in spinal cord. This study examined the effects of intrathecal treatment with group …