Gastrodin alleviates inflammatory injury of cardiomyocytes in septic shock mice via inhibiting NLRP3 expression

F Shao, L Zhou, Y Zhang, H Chen, Y Zhang… - In Vitro Cellular & …, 2021 - Springer
Septic shock leads to myocardial dysfunction and induces inflammation. Nod-like receptor
family pyrin domain-containing 3 (NLRP3) inflammasomes are involved in inflammation, and …

Gastrodin ameliorates microvascular reperfusion injury–induced pyroptosis by regulating the NLRP3/caspase-1 pathway

W Sun, H Lu, L Lyu, P Yang, Z Lin, L Li, L Sun… - Journal of physiology and …, 2019 - Springer
Inflammation is a pivotal feature of myocardial reperfusion–induced microvascular injury and
dysfunction. However, the molecular mechanisms by which myocardial reperfusion triggered …

Ginsenoside Rg1 attenuates cardiomyocyte apoptosis and inflammation via the TLR4/NF‐kB/NLRP3 pathway

M Luo, D Yan, Q Sun, J Tao, L Xu… - Journal of cellular …, 2020 - Wiley Online Library
Sepsis‐induced myocardial dysfunction (SIMD) causes high mortality in seriously ill patients.
Ginsenoside Rg1 has been proven to have effective anti‐inflammatory and antiapoptotic …

Emodin alleviates LPS‐induced myocardial injury through inhibition of NLRP3 inflammasome activation

S Dai, B Ye, L Chen, G Hong, G Zhao… - Phytotherapy …, 2021 - Wiley Online Library
Myocardial injury and cardiovascular dysfunction are serious consequences of sepsis and
contribute to high mortality. Currently, the pathogenesis of myocardial injury in sepsis is still …

The Protective Effects of Goitrin on LPS-Induced Septic Shock in C57BL/6J Mice via Caspase-11 Non-Canonical Inflammasome Inhibition

D Ruan, J Yang, Q Luo, Y Shi, L Ding, Z Wang, R Wang… - Molecules, 2023 - mdpi.com
Septic shock is defined as a subset of sepsis, which is associated with a considerably high
mortality risk. The caspase-11 non-canonical inflammasome is sensed and activated by …

Gastrodin attenuation of the inflammatory response in H9c2 cardiomyocytes involves inhibition of NF-κB and MAPKs activation via the phosphatidylinositol 3-kinase …

P Yang, Y Han, L Gui, J Sun, Y Chen, R Song… - Biochemical …, 2013 - Elsevier
The phenolic glucoside gastrodin, a main constituent of a Chinese traditional herbal
medicine, has been known to display several biological and pharmacological properties …

Tangeretin attenuates acute lung injury in septic mice by inhibiting ROS-mediated NLRP3 inflammasome activation via regulating PLK1/AMPK/DRP1 signaling axis

Y Liu, Y Zhang, G You, D Zheng, Z He, W Guo… - Inflammation …, 2024 - Springer
Objective NLRP3 inflammasome-mediated pyroptosis of macrophage acts essential roles in
the progression of sepsis-induced acute lung injury (ALI). Tangeretin (TAN), enriched in …

[HTML][HTML] NLRP3 inflammasome involves in the pathophysiology of sepsis-induced myocardial dysfunction by multiple mechanisms

H Zhang, J Liao, L Jin, Y Lin - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Sepsis-induced myocardial dysfunction (SIMD) is one of the serious health-affecting
problems worldwide. At present, the mechanisms of SIMD are still not clearly elucidated. The …

Naoxintong attenuates Ischaemia/reperfusion injury through inhibiting NLRP 3 inflammasome activation

Y Wang, X Yan, S Mi, Z Li, Y Wang… - Journal of Cellular …, 2017 - Wiley Online Library
Naoxintong (NXT) is a Chinese Materia Medica standardized product extracted from 16
various kinds of Chinese traditional herbal medicines including Salvia miltiorrhiza, Angelica …

Emodin Attenuates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis Signaling Pathway In vitro and In vivo

Y Liu, L Shang, J Zhou, G Pan, F Zhou, S Yang - Inflammation, 2022 - Springer
Emodin, the effective component of the traditional Chinese medicine Dahuang, has anti-
inflammatory effects. However, the protective effects and potential mechanisms of emodin …