Tunneling nanotubes: a versatile target for cancer therapy

P Sahu, SR Jena, L Samanta - Current Cancer Drug Targets, 2018 - ingentaconnect.com
Currently Cancer is the leading cause of death worldwide. Malignancy or cancer is a class of
diseases characterized by uncontrolled cell growth that eventually invade other tissues and …

Tunneling nanotubes: The intercellular conduits contributing to cancer pathogenesis and its therapy

PK Melwani, BN Pandey - Biochimica et Biophysica Acta (BBA)-Reviews …, 2023 - Elsevier
Tunneling nanotubes (TNTs) are intercellular conduits, which meet the communication
needs of non-adjacent cells situated in the same tissue but at distances up to a few hundred …

Tunneling nanotubes: a new target for nanomedicine?

I Ottonelli, R Caraffi, G Tosi, MA Vandelli… - International Journal of …, 2022 - mdpi.com
Tunneling nanotubes (TNTs), discovered in 2004, are thin, long protrusions between cells
utilized for intercellular transfer and communication. These newly discovered structures …

Intercellular communication in the brain through tunneling nanotubes

KE Khattar, J Safi, AM Rodriguez, ML Vignais - Cancers, 2022 - mdpi.com
Simple Summary Tunneling nanotubes (TNTs) are a means of cell communication which
have been recently discovered. They allow the intercellular trafficking of many types of …

Opportunities and challenges in tunneling nanotubes research: how far from clinical application?

X Han, X Wang - International journal of molecular sciences, 2021 - mdpi.com
Tunneling nanotubes (TNTs) are recognized long membrane nanotubes connecting
distance cells. In the last decade, growing evidence has shown that these subcellular …

Tunneling nanotubes: the fuel of tumor progression?

G Pinto, C Brou, C Zurzolo - Trends in cancer, 2020 - cell.com
Tunneling nanotubes (TNTs) are thin membrane tubes connecting remote cells and allowing
the transfer of cellular content. TNTs have been reported in several cancer in vitro, ex vivo …

Tunneling Nanotubes: A new paradigm for studying intercellular communication and therapeutics in cancer

E Lou, S Fujisawa, A Barlas, Y Romin… - … & integrative biology, 2012 - Taylor & Francis
Tunneling nanotubes are actin-based cytoplasmic extensions that function as intercellular
channels in a wide variety of cell types. There is a renewed and keen interest in the …

Cellular and molecular networking within the ecosystem of cancer cell communication via tunneling nanotubes

E Lou, E Zhai, A Sarkari, S Desir, P Wong… - Frontiers in cell and …, 2018 - frontiersin.org
Intercellular communication is vital to the ecosystem of cancer cell organization and
invasion. Identification of key cellular cargo and their varied modes of transport are important …

Emerging physiological and pathological implications of tunneling nanotubes formation between cells

S Sisakhtnezhad, L Khosravi - European journal of cell biology, 2015 - Elsevier
Cell-to-cell communication is a critical requirement to coordinate behaviors of the cells in a
community and thereby achieve tissue homeostasis and conservation of the multicellular …

Tunneling nanotubes, a novel mode of tumor cell–macrophage communication in tumor cell invasion

SJ Hanna, K McCoy-Simandle, E Leung… - Journal of cell …, 2019 - journals.biologists.com
The interaction between tumor cells and macrophages is crucial in promoting tumor invasion
and metastasis. In this study, we examined a novel mechanism of intercellular …