Four non-enzymatic proteins form the structural core of the TCR signaling machinery, linking
antigen-receptor activation to signaling. These four proteins, each with well defined protein …

The antigen receptors on T and B lymphocytes (TCR and BCR) are multimeric complexes
composed of a receptor module associated with various signaling proteins (CD3 γδε, and …

T cells are essential for the adaptive immune response to pathogens. However,
dysfunctional T cell activity has been implicated in numerous diseases, including the failure …

The adaptor molecule SLAP and E3 ubiquitin ligase c-Cbl each regulate expression of T cell
receptor (TCR)–CD3 on thymocytes. Here we provide genetic and biochemical evidence …

▪ Abstract The initiation of biochemical signal transduction following ligation of surface
receptors with intrinsic cytoplasmic tyrosine kinase activity is common for many cell types. T …

Src-like adaptor protein (SLAP) down-regulates expression of the T cell receptor (TCR)–
CD3 complex during a specific stage of thymocyte development when the TCR repertoire is …

Of the past several years progress in understanding TCR signal transduction has led to the
discovery of new kinases, adapter molecules and multiple signaling pathways. The study of …

A key molecule necessary for activation of T lymphocytes through their antigen-specific T
cell receptor (TCR) is the transmembrane adaptor protein LAT (linker for activation of T …

Transmembrane adaptor molecule LAT (linker for activation of T cells) forms a central
scaffold for signaling protein complexes that accumulate in the vicinity of activated T cell …

The mechanisms by which a T cell detects antigen using its T cell antigen receptor (TCR)
are crucial to our understanding of immunity and the harnessing of T cells therapeutically. A …