The terminal complement complex (TCC) has been described as a potential driver in the
pathogenesis of posttraumatic osteoarthritis (PTOA). However, sublytic TCC deposition …

The terminal complement complex (TCC) is formed on activation of the complement system,
a crucial arm of innate immunity. TCC formation on cell membranes results in a …

There is increasing evidence that complement may play a role in bone development. Our
previous studies demonstrated that the key complement receptor C5aR was strongly …

Purpose: A recent study has identified a central role for the activation of the complement
system in the pathogenesis of OA, finding an abnormally high expression and activation of …

Objective To investigate complement (C) factors (F) and their activation fragments
expression in OA joint tissues. Design Immunohistochemistry and quantitative imaging were …

Objective Innate immune response and particularly terminal complement complex (TCC)
deposition are thought to be involved in the pathogenesis of posttraumatic osteoarthritis …

Background The complement system is suggested to be involved in the pathogenesis of
osteoarthritis (OA), and proinflammatory cytokines may play a role in OA development by …

Purpose: The complement system is part of the innate immune system. It comprises a large
number of specific proteins which help to initiate an inflammatory response, opsonize and …

Objective Tissue-based xenografts such as cartilage are rejected within weeks by humoral
and cellular mechanisms that preclude its clinical application in regenerative medicine. The …

Degenerative alterations in articular cartilage are involved in the pathogenesis of
osteoarthritis. The present study aimed to evaluate the role of complement component 5a …