We have reported that anterior cruciate ligament (ACL) injury leads to the differential
dysregulation of the complement system in the synovium as compared to meniscus tear (MT) …

The anaphylatoxin receptor C5aR1 plays an important role not only in innate immune
responses, but also in bone metabolism and fracture healing, being highly expressed on …

Degenerative joint diseases such as osteoarthritis are characterised by aberrant region-
specific bone formation and abnormal bone mineral content. A recent study suggested a role …

C1q deficiency is the strongest known risk factor for SLE (systemic lupus erythematosus) but
its endogenous cellular origin remains limitedly understood. In the present study we …

Objective. Complement activation products contribute to a large number of inflammatory
diseases, including RA. We have investigated whether osteoprotegerin (OPG) may concur …

The complement system is thought to be a major physiological mediator of injury in a
number of diseases including rheumatoid arthritis (RA). The membrane attack complex …

Objective We previously demonstrated that carboxypeptidase B (CPB) protects against joint
erosion in rheumatoid arthritis by inactivating complement component C5a. We also found …

Macrophages are important for repair of injured tissues, but their role in healing after
surgical repair of musculoskeletal tissues is not well understood. We used single cell RNA …

An integral part of innate immunity is the complement system, a defence system, consisting
of fluid-phase and cell surface-bound proteins. Its role to ensure adequate responses to …

The complement system is important for the host defence against infection as well as for the
development of inflammatory diseases. Here we show that C1q/TNF-related protein 6 …