Activation of each complement initiation pathway (classical, alternative, and lectin) can lead
to the generation of bioactive fragments with resulting inflammation in target organs. The …

“Carboxypeptidase B plays a protective role in osteoarthritis by inhibiting formation of the
complement membrane attack complex, and potentially through additional anti-inflammatory …

Age-related and chemotherapy-induced bone loss depends on cellular senescence and the
cell secretory phenotype. However, the factors secreted in the senescent microenvironment …

Objectives: To assess the human complement inhibitor C4b-binding protein (C4BP) for
treatment of arthritis. Methods: We have used two mouse models of rheumatoid arthritis (RA) …

Objective Cartilage oligomeric matrix protein (COMP) is a structural component of cartilage,
where it catalyzes collagen fibrillogenesis. Elevated amounts of COMP are found in serum …

Background Primary osteoarthritis (OA) is the most common cause of knee arthritis
worldwide. The knee synovial fluid complement C3-β chain levels have been shown to …

Objective. To investigate biomarker patterns in rheumatoid arthritis (RA) with extraarticular
manifestations. Methods. Cartilage oligomeric matrix protein (COMP), COMP-C3b, and …

Introduction Patients with anterior cruciate ligament injury are at high risk of posttraumatic
osteoarthritis and their response to reconstructive surgery and rehabilitation vary. Proteins …

Synovial inflammation plays a critical role in the symptoms and structural progression of
arthritis which leads to irreversible damage of the adjacent cartilage and bone. Activation of …

Collagen IX containing the N-terminal noncollagenous domain 4 (NC4) is unique to
cartilage and a member of the family of fibril-associated collagens with both collagenous …