Effects of the apolipoprotein (a) size polymorphism on the lipoprotein (a) concentration in 7 ethnic groups

C Sandholzer, DM Hallman, N Saha, G Sigurdsson… - Human genetics, 1991 - Springer
Summary Apolipoprotein (a)[apo (a)] exhibits a genetic size polymorphism explaining about
40% of the variability in lipoprotein (a)[Lp (a)] concentration in Tyroleans. Lp (a) …

Contribution of the apo [a] phenotype to plasma Lp [a] concentrations shows considerable ethnic variation.

M Helmhold, J Bigge, R Muche, J Mainoo, J Thiery… - Journal of lipid …, 1991 - Elsevier
Apolipoprotein [a] polymorphism has been investigated by sodium dodecyl sulfate
polyacrylamide (5.37%) gel electrophoresis and immunoblotting using a standardized …

The apolipoprotein (a) gene: a transcribed hypervariable locus controlling plasma lipoprotein (a) concentration

HG Kraft, S Köchl, HJ Menzel, C Sandholzer… - Human genetics, 1992 - Springer
Abstract Lipoprotein (a)[Lp (a)] is a quantitative trait in human plasma. Lp (a) consists of a
low-density lipoprotein and the plasminogen-related apolipoprotein (a)[apo (a)]. The apo (a) …

Apolipoprotein (a) gene accounts for greater than 90% of the variation in plasma lipoprotein (a) concentrations.

E Boerwinkle, CC Leffert, J Lin… - The Journal of …, 1992 - Am Soc Clin Investig
Plasma lipoprotein (a)[Lp (a)], a low density lipoprotein particle with an attached
apolipoprotein (a)[apo (a)], varies widely in concentration between individuals. These …

Genetics of the quantitative Lp (a) lipoprotein trait: III. Contribution of Lp (a) glycoprotein phenotypes to normal lipid variation

E Boerwinkle, HJ Menzel, HG Kraft, G Utermann - Human genetics, 1989 - Springer
Summary Apolipoprotein (a)[apo (a)] is a large serum glycoprotein with several genetically
determined isoforms differing in their apparent molecular weight. We determined the effects …

Sequence polymorphisms in the apolipoprotein (a) gene. Evidence for dissociation between apolipoprotein (a) size and plasma lipoprotein (a) levels.

JC Cohen, G Chiesa, HH Hobbs - The Journal of clinical …, 1993 - Am Soc Clin Investig
Apolipoprotein (a)[apo (a)], an apolipoprotein unique to lipoprotein (a)[Lp (a)], is highly
polymorphic in size. Previous studies have indicated that the size of the apo (a) gene tends …

Genetic architecture and evolution of the lipoprotein (a) trait

G Utermann - Current opinion in lipidology, 1999 - journals.lww.com
Apolipoprotein (a) is coded by one of the most polymorphic genes known in humans. In
white and Asian populations variation in this gene is the major determinant of the plasma …

Apolipoprotein (a) phenotypes, Lp (a) concentration and plasma lipid levels in relation to coronary heart disease in a Chinese population: evidence for the role of the …

CH Sandholzer, E Boerwinkle, N Saha… - The Journal of …, 1992 - Am Soc Clin Investig
Elevated lipoprotein (a)(Lp [a]) concentrations are associated with premature coronary heart
disease (CHD). In the general population, Lp (a) levels are largely determined by alleles at …

[PDF][PDF] The Apo (a) gene is the major determinant of variation in plasma Lp (a) levels in African Americans

V Mooser, D Scheer, SM Marcovina, J Wang… - The American Journal of …, 1997 - cell.com
The distributions of plasma lipoprotein (a), or Lp (a), levels differ significantly among ethnic
groups. Individuals of African descent have a two-to threefold higher mean plasma level of …

Comparative analysis of the apo (a) gene, apo (a) glycoprotein, and plasma concentrations of Lp (a) in three ethnic groups. Evidence for no common" null" allele at the …

A Gaw, E Boerwinkle, JC Cohen… - Journal of Clinical …, 1994 - ncbi.nlm.nih.gov
Distributions of plasma lipoprotein (a)(Lp [a]) concentrations exhibit marked interracial
differences. Apolipoprotein (a)(apo [a]), the unique constituent of Lp (a), is highly …