Using decision tree aggregation with random forest model to identify gut microbes associated with colorectal cancer

D Ai, H Pan, R Han, X Li, G Liu, LC Xia - Genes, 2019 - mdpi.com
The imbalance of human gut microbiota has been associated with colorectal cancer. In
recent years, metagenomics research has provided a large amount of scientific data …

Microbiota-based model improves the sensitivity of fecal immunochemical test for detecting colonic lesions

NT Baxter, MT Ruffin, MAM Rogers, PD Schloss - Genome medicine, 2016 - Springer
Background Colorectal cancer (CRC) is the second leading cause of death among cancers
in the United States. Although individuals diagnosed early have a greater than 90% chance …

Identification of colorectal cancer progression-associated intestinal microbiome and predictive signature construction

J Liu, X Huang, C Chen, Z Wang, Z Huang… - Journal of Translational …, 2023 - Springer
Objective The relationship between intestinal microbiome and colorectal cancer (CRC)
progression is unclear. This study aims to identify the intestinal microbiome associated with …

Towards a metagenomics machine learning interpretable model for understanding the transition from adenoma to colorectal cancer

CS Casimiro-Soriguer, C Loucera, M Peña-Chilet… - Scientific reports, 2022 - nature.com
Gut microbiome is gaining interest because of its links with several diseases, including
colorectal cancer (CRC), as well as the possibility of being used to obtain non-intrusive …

Identification of host gene-microbiome associations in colorectal cancer patients using mendelian randomization

Y Xiang, C Zhang, J Wang, Y Cheng, L Wang… - Journal of translational …, 2023 - Springer
Background There are many studies indicating that alterations in the abundance of certain
gut microbiota are associated with colorectal cancer (CRC). However, a causal relationship …

Differential mucosal microbiome profiles across stages of human colorectal cancer

M Zhang, Y Lv, S Hou, Y Liu, Y Wang, X Wan - Life, 2021 - mdpi.com
Emerging evidences link gut microbiota to colorectal cancer (CRC) initiation and
development. However, the CRC stage-and spatial-specific bacterial taxa were less …

Dysbiosis of gut microbiota in promoting the development of colorectal cancer

S Zou, L Fang, MH Lee - Gastroenterology report, 2018 - academic.oup.com
Gastrointestinal microbiome, containing at least 100 trillion bacteria, resides in the mucosal
surface of human intestine. Recent studies show that perturbations in the microbiota may …

Mucosal microbiota of intestinal polyps reveals putative biomarkers of colorectal cancer

M Mangifesta, L Mancabelli, C Milani, F Gaiani… - Scientific reports, 2018 - nature.com
The human intestine retains a complex microbial ecosystem, which performs crucial
functions that impact on host health. Several studies have indicated that intestinal dysbiosis …

Gut microbiota profiles in early-and late-onset colorectal cancer: a potential diagnostic biomarker in the future

M Abdullah, N Sukartini, SA Nursyirwan, RR Pribadi… - Digestion, 2021 - karger.com
Background: Researchers believe the role of gut microbiota dysbiosis in the raised
incidence of early-onset colorectal cancer (EOCRC). The development of EOCRC may be …

Understanding the microbiome: emerging biomarkers for exploiting the microbiota for personalized medicine against cancer

M Rajpoot, AK Sharma, A Sharma, GK Gupta - Seminars in cancer biology, 2018 - Elsevier
The human body is a home to more than 1 trillion microbes with a diverse variety of
commensal microbes that play a crucial role towards the health of the individual. These …