Rats allowed extended access to cocaine self-administration develop a number of
symptoms of addiction, such as greater susceptibility to drug-induced relapse. Using the …

Relapse to drug use following prolonged periods of abstinence results, in part, from the
ability of contextual cues paired previously with self-administered drug to elicit drug craving …

Rationale Rats develop preferences for places associated with the immediate rewarding
effects of cocaine and aversions for places paired with the drug's delayed negative effects …

Rationale The place conditioning procedure is increasingly used to study relapse in drug
seeking in mice. However, the retention course of drug-induced place preference has not …

To explore the way in which drugs act to reinstate drug-seeking behavior, we studied drug-
induced reinstatement of a cocaine-induced conditioned place preference (CPP). In a series …

We have previously shown that extended‐access subjects exhibit heightened motivation for
cocaine in the runway model, as reflected by reduced number of retreats. This heightened …

Drug reinforcement learning is relevant for the development of addiction. The present study
investigated how changes in the magnitude of drug‐unconditioned stimulus during …

The rewarding effect of cocaine as reflected by the development of conditioned place
preference was examined in C57BL/6J and 129/J mice. Cocaine was administered in a …

To explore sex differences in reinstatement of conditioned place preference, we subjected
intact male and female Long Evans rats to an extended conditioned place preference (CPP) …

Cocaine-treated rats acquired a preference for cocaine-associated contextual stimuli (CS)
relative to saline-injected control rats. However, when animals were given repeated tests for …