Obesity is associated with increased incidence and severity of triple-negative breast cancer
(TNBC); however, mechanisms underlying this relationship are incompletely understood …

Adipose tissue is the primary source of many pro-inflammatory cytokines in obesity.
Macrophage numbers and pro-inflammatory gene expression are positively associated with …

During carcinogenesis, tumors induce dysfunctional development of hematopoietic cells.
Myeloid lineage cells, in the form of myeloid derived suppressor cells (MDSCs) and …

Obesity is one of the most important preventable causes of cancer and the most significant
risk factor for breast cancer in postmenopausal women. Compared with lean women, obese …

Breast cancer (BC) remains the leading cause of cancer-related deaths among women, and
the chances to develop it are duplicated by obesity. Still, the impact of obesity during BC …

Recent studies indicate that adipose tissue in obesity promotes breast cancer progression
by secreting protumorigenic chemokines, growth factors, and fatty acids. However, the …

Growing evidence demonstrates a strong correlation between obesity and an increased risk
of breast cancer, although the mechanisms involved have not been completely elucidated …

Obesity is associated with adipose inflammation, defined by macrophages encircling dead
adipocytes, as well as extracellular matrix (ECM) remodeling and increased risk of breast …

Obesity is associated with increased cancer incidence and progression. However, the
relationship between adiposity and cancer remains poorly understood at the mechanistic …

Consequences of the obesity epidemic on cancer morbidity and mortality are not fully
appreciated. Obesity is a risk factor for many cancers, but the mechanisms by which it …