Many epidemiological studies show a positive connection between cardiovascular diseases
and risk of osteoporosis, suggesting a role of hyperlipidemia and/or hypercholesterolemia in …

Bone is a complex tissue composing of mineralized bone, bone cells, hematopoietic cells,
marrow adipocytes, and supportive stromal cells. The homeostasis of bone and marrow …

As the incidence of osteoporosis (OP) and hypercholesterolaemia in men has increased,
male OP has drawn more attention from clinicians worldwide. The present study sought to …

The association between lipid and bone metabolism has become an increasing focus of
interest in recent years, and accumulating evidence has shown that atherosclerosis (AS) …

Beyond being aging-related diseases, atherosclerosis and osteoporosis share common
pathogenetic pathways implicated in bone and vascular mineralization. However, the …

Osteoporosis and age-related bone loss are important public health concerns. Therefore,
there is a high level of interest in the development of medical interventions and lifestyle …

Abstract Background Statins are 3‐Hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA)
reductase inhibitors blocking cholesterol biosynthesis in hepatic cells, thereby causing an …

Bone is a dynamic tissue and is constantly being remodeled by bone cells. Metabolic
reprogramming plays a critical role in the activation of these bone cells and skeletal …

Osteoporosis is a common disease in the elderly population. The progress of this disease
results in the reduction of bone mass and can increase the incidence of fractures. Drugs …

Recent in vitro and animal studies suggest that cholesterol and its metabolites inhibit the
functional activity of osteoblasts and thereby induce reduced bone mineralization. However …