Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous
compounds, including lipid esters. Physiological functions of carboxylesterases in lipid …

Carboxylesterases (CES) are a well recognized, yet incompletely characterized family of
proteins that catalyze neutral lipid hydrolysis. Some CES have well-defined roles in …

Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …

Our understanding of the detailed recognition and processing of clinically useful therapeutic
agents has grown rapidly in recent years, and we are now able to begin to apply this …

Human carboxylesterase 1 (hCE1) is a serine esterase involved in both drug metabolism
and activation, as well as other biological processes. hCE1 catalyses the hydrolysis of …

This review covers current developments in molecular-based studies of the structure and
function of carboxylesterases. To allay the confusion of the classic classification of …

Serine hydrolases are a large family of multifunctional enzymes known to influence obesity.
Here, we performed activity-based protein profiling to assess the functional level of serine …

Increased lipogenesis, together with hyperlipidemia and increased fat deposition, contribute
to obesity and associated metabolic disorders including nonalcoholic fatty liver disease …

Human carboxylesterase (CES) 1 and CES2 are members of the serine hydrolase
superfamily, and both exhibit broad substrate specificity and are involved in xenobiotic and …

Human carboxylesterase 1 (hCE1) is a drug and endobiotic-processing serine hydrolase
that exhibits relatively broad substrate specificity. It has been implicated in a variety of …