The mechanisms of drug interaction at major points within the pharmacodynamic phase of
drug activity are reviewed. A series of tables list common drug interactions and figures are …

Pharmacokinetic investigations of suspected or potential drug interactions are designed to
determine the effect of one drug on the absorption, distribution, metabolism, or excretion of …

Drug interactions are usually classified as either pharmacokinetic or pharmacodynamic in
nature. Interactions in which one drug affects the absorption, distribution metabolism, or …

Open any current medical journal and one is reminded that the coadministration of two or
more drugs can either cause deleterious effects or lead to ineffective therapy. Those …

HOW CAN DRUG INTERACTION OCCUR? Drug interaction may be a direct effect of one
compound upon another, by modification of intestinal absorption, by affecting the transport of …

Some drugs influence the gastro-intestinal absorption, distribution, metabolism or renal
excretion of other drugs, ie processes involved in pharmacokinetic interactions. The clinical …

One drug may markedly influence the pharmacologic response to another in man. A variety
of factors have been implicated in such drug interactions. The effective and safe use of …

The current therapeutic practice of multiple drug therapy results in a reasonable probability
of a drug~ lrug interaction, although few are clinically significant. Despite numerous reports …

It was proposed in the first part of this review~ cElnay and D'Arcy, 1980) that drug
interactions may be divided &to 3 categories, ie pharmacokinetic, pha~ acodyn~ ic and a …

The problem of fixed drug combinations must be considered in the problems of drug
interaction. Prolonged administration of one compound in a fixed ratio with others may …