Hypermethylation of CpG islands is associated with silencing of various tumor suppressor
genes. Recent studies on colorectal and gastric cancer have identified a CpG island …

Hypermethylation of CpG islands in gene promoters is associated with silencing of various
tumour suppressor genes. Recent studies of colorectal and gastric carcinomas have defined …

Aberrant methylation of 5′ CpG islands is thought to play an important role in the
inactivation of tumor suppressor genes in cancer. In colorectal cancer, a group of tumors is …

BACKGROUND The authors purpose in this study was to clarify the difference in terms of
clinicopathologic features between gastric cancer (GC) with high numbers of DNA …

BACKGROUND Transcriptional silencing by CpG‐island hypermethylation now is believed
to be an important mechanism of tumorigenesis. To date, studies on CpG‐island …

Transcriptional silencing by CpG island hypermethylation is a potential mechanism for the
inactivation of tumor-related genes. Virtually, all types of human cancers show CpG island …

BACKGROUND The CpG island methylator phenotype (CIMP), which is characterized by
simultaneous methylation of the CpG islands of multiple genes, has been recognized as one …

Gastric carcinogenesis involves multiple genetic and epigenetic alterations. Epigenetic
silencing of tumor-related genes due to CpG island methylation (CIM) has been recently …

Mounting evidence suggests that aberrant methylation of CpG islands is a major pathway
leading to the inactivation of tumor suppressor genes and the development of cancer …

The presence of high levels of aberrant DNA methylation in gastric mucosae correlates with
risk of gastric cancer. Some gastric cancers are known to have methylation of multiple CpG …