Background Health state utilities (HSU) are a health-related quality-of-life (HRQoL) input for
cost-utility analyses used for resource allocation decisions, including medication …

Background: It is a familiar story. A promising multiple sclerosis (MS) treatment clears the
three regulatory hurdles of safety, quality and efficacy, only to fall at the fourth: cost …

Background A major debate in the quality-adjusted life-year (QALY) literature concerns
whose preferences should be used to estimate health state values (HSVs) and to calculate …

Background: Walking impairment has a major influence on the quality of life of people with
multiple sclerosis (MS). The Multiple Sclerosis Walking Scale (MSWS-12) assesses the …

Background Mapping of patient-reported outcomes to the five-dimension EuroQol (EQ-5D)
health index is increasingly being used for understanding the relationship of outcomes to …

Background Multiple sclerosis (MS) is a chronic neurological disorder, which can lead to a
wide range of disabling symptoms. The condition has a significant negative impact on health …

Cognitive impairment interferes with a patientLs attention span, decision-making ability,
understanding and concentration, impacting on their day-to-day life 1. Nearly half of patients …

Background: Mapping can be performed to predict utility values from condition-specific
measures when preference-based measures are absent. A previously developed algorithm …

Background and aims Relapses are an important clinical feature of multiple sclerosis (MS)
that result in temporary negative changes in quality of life (QoL), measured by health state …

Introduction When health state utility values for comorbid health conditions are not available,
data from cohorts with single conditions are used to estimate scores. The methods used can …