Aims: This paper evaluates the impact of multiple sclerosis (MS) in Ireland, and estimates
the associated direct, indirect, and intangible costs to society based on a large nationally …

Background Many intervention-based studies aiming to improve mental health do not
include a multi-attribute utility instrument (MAUI) that produces quality-adjusted life-years …

Objectives Some argue that generic preference-based measures (PBMs) are not sensitive to
certain disease-specific improvements. To overcome this problem, new condition-specific …

The NICE Guide to the Methods of Technology Appraisal expresses a preference for using
the EQ-5D for adult populations to estimate the Quality Adjusted Life Year (QALY) impact of …

Abstract Background/Objective Patients with multiple sclerosis (MS) tend to have
significantly lower health-related quality of life, increased mortality and morbidity, and …

Background: In Europe, there exists considerable variability in access to care and treatment
for multiple sclerosis (MS). Objectives: To improve this situation, we identified key issues …

Background. Reliably mapping from generic or diseasespecific health status measures into
health state utilities would assist health economists. Existing studies mainly use ordinary …

Cost-effectiveness analysis (CEA) can be a powerful analytic tool for assessing the value of
health care interventions when used in conjunction with efficacy, safety, and other …

Background Administrative healthcare claims data provide a mechanism for assessing and
monitoring multiple sclerosis (MS) disease status across large, clinically representative “real …

Background Mapping of health-related quality-of-life measures to health utility values can
facilitate cost-utility evaluation. Regression-based methods tend to lead to shrinkage of …