Background Birthweight marks an important milestone of health across the lifespan,
including cardiometabolic disease risk in later life. The placenta, a transient organ at the …

Aim: To identify placental DNA methylation changes that are associated with early
pregnancy maternal dyslipidemia. Materials & methods: We analyzed placental genome …

Background Maternal obesity prior to or during pregnancy influences fetal growth,
predisposing the offspring to increased risk for obesity across the life course. Placental …

Inherent genetic programming and environmental factors affect fetal growth in utero.
Epidemiologic data in growth-altered fetuses, either intrauterine growth restricted (IUGR) or …

Being born small (SGA) or large for gestational age (LGA) is associated with adverse birth
outcomes and metabolic diseases in later life of the offspring. It is known that aberrations in …

The placenta undergoes many changes throughout gestation to support the evolving needs
of the foetus. There is also a growing appreciation that male and female foetuses develop …

This study evaluated the hypothesis that prenatal maternal socioeconomic status (SES)
adversity is associated with DNA methylation in the placenta. SES adversity was defined by …

The human placenta is a maternal-fetal organ essential for normal fetal development and
maternal health. During pregnancy, the placenta undergoes many structural and functional …

Background The human placenta facilitates the exchange of nutrients, gas and waste
between the fetal and maternal circulations. It also protects the fetus from the maternal …

Background Preterm birth is a significant clinical problem and an enormous burden on
society, affecting one in eight pregnant women and their newborns. Despite decades of …