Previously, defined naturally occurring isoforms of allergenic proteins were classified as
hypoallergens and therefore suggested as an agent for immunotherapy in the future. In this …

Background: The major allergen of birch pollen, Bet v 1, is present in structurally slightly
different isoforms. It has been postulated that certain isoforms show a distinct ability to bind …

Abstract Background Pollen of the European white birch (Betula pendula, syn. B. verrucosa)
is an important cause of hay fever. The main allergen is Bet v 1, member of the pathogenesis …

BACKGROUND: At least 100 million patients suffer from birch pollen allergy. OBJECTIVE:
Rational design of recombinant derivatives of the major birch pollen allergen, Bet v 1 …

Bet v 1, the major birch pollen allergen, represents one of the most prominent allergens. It is
recognized by serum IgE from more than 95% of patients allergic to tree pollen and almost …

Background Blocking the major cat allergen, Fel d 1, with mAbs was effective in preventing
an acute cat allergic response. Objectives This study sought to extend the allergen-specific …

Background Characterization of IgE-binding epitopes of allergens and determination of their
patient-specific relevance is crucial for the diagnosis and treatment of allergy. Objective We …

We dissected the T cell activation potency and the immunoglobulin (Ig) E-binding properties
(allergenicity) of nine isoforms of Bet v 1 (Bet v 1a-Bet v 1l), the major birch pollen allergen …

Bet v 1, the single major allergen from birch pollen, shares IgE epitopes with all major tree
pollen allergens from closely related species such as alder, hazel, hornbeam, beech, and …

Background Bet v 1 is the main sensitizing allergen in birch pollen. Like many other major
allergens, it contains an immunodominant T cell–activating region (Bet v 1 142-156). Api g 1 …