Allergy prevalence has increased in industrialized countries. One contributing factor could
be pollution, which can cause nitration of allergens exogenously (in the air) or …

Bet v I, the major allergen of birch pollen, is a 17 kD cytosolic protein that is quantitatively
extracted from pollen grains by simply washing with water. The cDNA sequence¹ of Bet v I …

A high percentage of birch pollen allergic patients also experience food hypersensitivity
which results from common epitopes on the corresponding allergens. In order to analyze …

Background: Individual amino acid residues of the major birch pollen allergen, Bet v 1, have
been identified to be crucial for IgE recognition. The objective of the present study was to …

Background Genetic engineering of the major birch pollen allergen (Bet v 1) has led to the
generation of recombinant Bet v 1 derivatives with markedly reduced IgE‐binding capacity …

Despite a high similarity with homologous protein families, only few proteins trigger an
allergic immune response with characteristic TH2 polarization. This puzzling observation is …

Background The search for intrinsic factors, which account for a protein's capability to act as
an allergen, is ongoing. Fold stability has been identified as a molecular feature that affects …

An estimated 100 million individuals suffer from birch pollen allergy. Specific
immunotherapy, the only curative allergy treatment, can cause life‐threatening anaphylactic …

Background Allergen‐specific immunotherapy (AIT) with birch pollen generates Bet v 1‐
specific immunoglobulin (Ig) G4 which blocks IgE‐mediated hypersensitivity mechanisms …

Background: Previous work in type‐I pollen allergies has mainly focused on lymphocytes
and immune responses. Here, we begin to analyse with a systems biology view the …