Background: We analyzed the T cell activation potency and the IgE-binding properties
(allergenicity) of nine isoforms of Bet v 1, the major allergen of birch pollen. Methods: The …

Human type 1 immediate allergic response symptoms are caused by mediator release from
basophils and mast cells. This event is triggered by allergens aggregating preformed IgE …

Bet v 1 and homologous proteins represent major cross-reactive allergens for more than
95% of tree pollen-, fruit-, and vegetable-allergic individuals. To study the interaction of Bet v …

BACKGROUND: Several alternative mechanisms have been proposed to explain why some
proteins are able to induce a TH2-biased and IgE-mediated immune response. These …

Background Allergy vaccines should be easily applicable, safe, and efficacious. For Bet v 1–
mediated birch pollen and associated food allergies, a single wild-type allergen does not …

Background: We describe the production in Escherichia coli as a recombinant protein of
clinical grade wild-type Bet v 1a (rBet v 1a), to be used as a candidate vaccine against birch …

Background: Birch pollen allergy is one of the most common causes of spring pollinosis
often associated with hypersensitivity reactions to pollen of other Fagales species. Yet, only …

Many patients who have been sensitised to pollen, display allergic symptoms after ingestion
of certain plant food such as fresh fruit, vegetables and nuts. The cause is the cross-reactivity …

Birch pollinosis is often accompanied by hypersensitivity to fruit as a consequence of the
cross-reaction of pollen allergen-specific IgE antibodies with homologous food proteins. To …

Type I allergies are immunological disorders that afflict a quarter of the world's population.
Improved diagnosis of allergic diseases and the formulation of new therapeutic approaches …